RNA Aptamers: A Review of Recent Trends and Applications
RNA Aptamers: A Review of Recent Trends and Applications
复制标题
DOI：
10.1007/10_2012_136
复制
发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Lee, Yoon-Sik
中科院分区：
文献类型：
--
作者：
Kang, Kyung-Nam;Lee, Yoon-Sik
RNA 适体是通过称为 SELEX（通过实验富集进行配体系统进化）的体外选择过程衍生的小寡核苷酸，是治疗和诊断应用的重要候选者。 RNA适体对其靶分子具有高亲和力和特异性。在这篇综述中，我们描述了生成 RNA 适体的方法（SELEX 技术和改良的 SELEX 过程）以及对新生血管性年龄相关性黄斑变性 (AMD)、炎症性疾病和肥胖等疾病的治疗应用。我们还分析了积极追求基于适体的治疗方法的研究人员和组织（大学、研究机构、公司等）之间的社交网络。本研究提供了RNA适体最新研究趋势的相关信息。
RNA aptamers, small oligonucleotides derived by an in-vitro selection process called SELEX (Systematic Evolution of Ligands by EXperimental enrichment), are important candidates for therapeutic and diagnostic applications. RNA aptamers have high affinity and specificity for their target molecules. In this review, we describe methods for generating RNA aptamers (the SELEX technique and modified SELEX processes) and therapeutic applications for diseases such as neovascular age-related macular degeneration (AMD), inflammatory diseases, and obesity. We also analyze the social networks among researchers and organizations (universities, research institutes, firms, etc.) that are active in the pursuit of aptamer-based therapeutic approaches. This study provides relevant information on recent research trends in RNA aptamers.