Infection of B Cells With Hepatitis C Virus for the Development of Lymphoproliferative Disorders in Patients With Chronic Hepatitis C
Infection of B Cells With Hepatitis C Virus for the Development of Lymphoproliferative Disorders in Patients With Chronic Hepatitis C
复制标题
DOI：
10.1002/jmv.21388
复制
发表时间：
2009-04-01
影响因子：
12.7
通讯作者：
Imawari, Michio
中科院分区：
文献类型：
--
作者：
Inokuchi, Momoko;Ito, Takayoshi;Imawari, Michio
丙型肝炎病毒（HCV）感染与淋巴组织增生性疾病有关，主要表现为原发性混合性冷球蛋白血症和B细胞非霍奇金淋巴瘤，但其致病机制尚不清楚。HCV可感染B细胞或与其细胞表面受体相互作用，并诱导淋巴细胞增殖。在75例持续HCV感染患者中评价了HCV感染B细胞对淋巴组织增生性疾病发展的影响。HCV感染更普遍（63%vs.16%，14%，17%，P < 0.05），HCVRNA水平较高（3.35 +/- 3.85 vs. 1.75 +/- 2.52、2.15 +/- 2.94或2.10 +/- 2.90 log拷贝/100 ng，各P < 0.01）。作为病毒复制标志物的负链HCV RNA在75例患者中的4例（5%）的B细胞中检测到。50例慢性丙型肝炎患者中淋巴组织增生性疾病的标志物比32例慢性B肝炎患者更常见，包括冷球蛋白血症（26%对0%，P < 0.001）、低CHE 50水平（48%对3%，P = 0.012）和B细胞克隆性（12%对0%，P < 0.01）。多因素分析显示，B细胞中HCV RNA是与至少一种淋巴细胞增殖标志物存在相关的独立因素（比值比：1.98 [95%可信区间：1.36-7.24]，P = 0.027）。根据所获得的结果，HCV感染B细胞将在淋巴组织增生性疾病的发展中发挥重要作用。81：619-627，2009. (C)2009 Wiley-Liss，Inc.
Infection with hepatitis C virus (HCV) is associated with lymphoproliferative disorders, represented by essential mixed cryoglobulinemia and B-cell non-Hodgkin's lymphoma, but the pathogenic mechanism remains obscure. HCV may infect B cells or interact with their cell surface receptors, and induce lymphoproliferation. The influence of HCV infection of B cells on the development of lymphoproliferative disorders was evaluated in 75 patients with persistent HCV infection. HCV infection was more prevalent (63% vs. 16%,14%, or 17% P < 0.05 for each), and HCV RNA levels were higher (3,35 +/- 3.85 vs. 1.75 +/- 2.52, 2.15 +/- 2.94 or 2.10 +/- 2.90 log copies/100 ng, P < 0.01 for each) in B cells than CD4(+), CD8(+) T cells or other cells. Negative-strand HCV RNA, as a marker of viral replication, was detected in B cells from four of the 75 (5%) patients. Markers for lymphoproliferative disorders were more frequent in the 50 patients with chronic hepatitis C than the 32 with chronic hepatitis B, including cryoglobulinemia (26% vs. 0%, P < 0.001), low CHE50 levels (48% vs. 3%, P = 0.012), and the clonality of B cells (12% vs. 0%, P < 0.01). By multivariate analysis, HCV RNA in B cells was an independent factor associated with the presence of at least one marker for lymphoproliferation (odds ratio: 1.98 [95% confidence interval: 1.36-7.24], P = 0.027). Based on the results obtained, the infection of B cells with HCV would play an important role in the development of lymphoproliferative disorders. J. Med. Virol .81:619-627, 2009. (C) 2009 Wiley-Liss, Inc.