Lactogenesis - The transition from pregnancy to lactation
Lactogenesis - The transition from pregnancy to lactation
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DOI：
10.1016/s0031-3955(05)70284-4
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发表时间：
2001-02-01
影响因子：
2.6
通讯作者：
Umemura, S
中科院分区：
文献类型：
--
作者：
Neville, MC;Morton, J;Umemura, S
哺乳期最关键的时期是从怀孕到哺乳期，通常被称为泌乳期II。这一过渡期包括乳房的所有有序变化，这些变化导致乳房分泌物的钠和氯含量立即下降，产后头两天分泌少量富含免疫球蛋白和其他保护物质的液体，以及通常从产后约40小时开始分泌的成分类似于真奶的产品的体积增加。这些变化是由分娩后孕酮(可能还有雌激素)的下降触发的，需要高水平的血浆催乳素。去除乳汁在这一过程中的作用尚不清楚，需要进行前瞻性的临床研究来评估这一重要参数。
The most critical time in the establishment of lactation is during the transition from pregnancy to lactation, often termed lactogenesis stage II. This transition consists of all orderly set of changes in the mammary,oland that result in an immediate decrease in the sodium and chloride content of the mammary secretion product, the secretion of scant amounts of a fluid high in immunoglobulins and other protective substances during the first 2 days post partum, and an increase in the volume of a product with a composition resembling true milk secreted usually starting about 40 hours post partum. These changes are triggered by the fall in progesterone, and possibly estrogen, following parturition and require high levels of plasma prolactin. The role of milk removal in this process is unclear and prospective clinical studies are needed to assess this important parameter.