Serum triglycerides and colorectal adenoma in a case-control study among cancer screening examinees (Japan)
Serum triglycerides and colorectal adenoma in a case-control study among cancer screening examinees (Japan)
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DOI：
10.1007/s10552-006-0065-z
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发表时间：
2006-12-01
影响因子：
2.3
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Otani, Tetsuya;Iwasaki, Motoki;Tsugane, Shoichiro
目的多数流行病学研究表明血清甘油三酯与大肠腺瘤相关。然而，吸烟是否可以改变这种联系尚不清楚。我们横断面调查的关联血清甘油三酯与腺瘤的吸烟status.Methods的风险，我们确定了782例新诊断的腺瘤的结直肠癌筛查计划的受检者。所有病例均通过放大结肠镜染色扩散确诊。我们从受检者中确定了738名无现患疾病或既往腺瘤病史的对照。他们提供了他们的生活方式信息和空腹血液样本来测量他们的血清甘油三酯。结果高甘油三酯血症与结直肠腺瘤相关（OR 1.5; 95% CI 1.1-2.0，最高四分位数与最低四分位数比较，P（trend，）0.030）。在三个或更多腺瘤病例和研究对照之间观察到更强的关联（OR 2.3; 95%CI 1.3-4.2，P（趋势，）< 0.0010）。按吸烟状况对研究对象进行分类后，发现有过吸烟史的受试者有显著的线性风险趋势（P（趋势），0.0018），但不吸烟者无此趋势（P（趋势），0.94; P（交互作用），0.067）。涉及血清甘油三酯水平升高的腺瘤发展可通过吸烟改变。
Objective Most epidemiologic studies have shown serum triglycerides to be associated with colorectal adenoma. However, whether the association can be modified by smoking is unknown. We cross-sectionally investigated the association of serum triglycerides with the risk of adenoma by smoking status.Methods We identified 782 newly diagnosed adenoma cases from the examinees of a colorectal cancer screening program. All cases were diagnosed by a magnifying colonoscopy with dye spreading. We determined 738 controls without present illness or past history of adenoma from among the examinees. They provided their lifestyle information and fasting blood samples to measure their serum triglycerides. We calculated odds ratios (OR) and 95% confidence intervals (CI) of colorectal adenoma for serum triglycerides.Results High serum triglycerides were associated with colorectal adenoma (OR 1.5; 95% CI 1.1-2.0 for the highest versus the lowest quartile, P (trend,) 0.030). A stronger association was observed between three or more adenoma cases and study controls (OR 2.3; 95% CI 1.3-4.2, P (trend,) < 0.0010). After classifying the study subjects by smoking status, a significant linear risk trend was found in ever-smokers (P (trend), 0.0018) but not in never-smokers (P (trend), 0.94; P (interaction), 0.067).Conclusions Our results suggested that a higher serum triglyceride level may be related to a larger number of adenomas. Adenoma development involving an elevated serum triglyceride level may be modified by smoking.