Inferring seizure frequency from brief EEG recordings.
Inferring seizure frequency from brief EEG recordings.
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从简短的脑电图记录推断癫痫发作频率。
DOI：
10.1097/wnp.0b013e3182767c35
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Cash,SydneyS
中科院分区：
文献类型：
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作者：
Westover,MBrandon;Bianchi,MattT;Shafi,Mouhsin;Hoch,DanielB;Cole,AndrewJ;Chiappa,Keith;Cash,SydneyS
常规脑电图仍然是治疗癫痫患者的一项基石测试。虽然罕见，但在这种短暂的脑电图中可能会观察到自限性发作(仅限于临床或心电图)。在这种情况下观察癫痫发作的含义，特别是在推断潜在癫痫发作频率方面，尚不清楚。由于患者报告的癫痫发作频率估计不准确，这个问题变得复杂起来。治疗临床医生常常想知道，单次癫痫发作是否表明癫痫发作非常频繁，或者是否意义较小。我们将概率推理的标准概念应用到一个简单的癫痫发作发生率模型中，为临床医生面对这种情况提供一些指导。我们的分析建立了在常规脑电中观察到一次癫痫发作所隐含的癫痫发生率的上下限。不足为奇的是，有了关于预期癫痫发生率的额外信息，这些界限可以进一步受到限制。这一框架应该有助于临床医生在常规脑电图单次癫痫发作的设定中应用更有原则的方法进行决策。
Routine EEGs remain a cornerstone test in caring for people with epilepsy. Although rare, a self-limited seizure (clinical or electrographic only) may be observed during such brief EEGs. The implications of observing a seizure in this situation, especially with respect to inferring the underlying seizure frequency, are unclear. The issue is complicated by the inaccuracy of patient-reported estimations of seizure frequency. The treating clinician is often left to wonder whether the single seizure indicates very frequent seizures, or if it is of lesser significance. We applied standard concepts of probabilistic inference to a simple model of seizure incidence to provide some guidance for clinicians facing this situation. Our analysis establishes upper and lower bounds on the seizure rate implied by observing a single seizure during routine EEG. Not surprisingly, with additional information regarding the expected seizure rate, these bounds can be further constrained. This framework should aid the clinician in applying a more principled approach toward decision making in the setting of a single seizure on a routine EEG.