Ankyrin protein networks in membrane formation and stabilization.
Ankyrin protein networks in membrane formation and stabilization.
复制标题
膜形成和稳定中的Ankyrin蛋白网络。
DOI：
10.1111/j.1582-4934.2009.00943.x
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发表时间：
2009-11
影响因子：
5.3
通讯作者：
Mohler PJ
中科院分区：
文献类型：
--
作者：
Cunha SR;Mohler PJ
在真核细胞中，锚蛋白作为衔接蛋白，将膜蛋白连接到细胞骨架上。这些衔接蛋白形成由整合膜蛋白、信号分子和细胞骨架成分组成的蛋白复合物。凭借其模块化结构和与许多蛋白质相互作用的能力，锚蛋白组织和稳定这些蛋白质网络，从而建立具有专门功能的膜结构域的基础设施。为此，锚蛋白与许多蛋白质，包括细胞骨架蛋白，细胞粘附分子和大结构蛋白合作。本文综述了锚蛋白与细胞骨架蛋白β-血影蛋白、L1细胞粘附分子和大肌原纤维蛋白obscurin相互作用相关的蛋白质网络的靶向和稳定性。这些相互作用的差异靶向心脏蛋白和神经元膜形成的意义也提出。最后，这篇评论的结论与人类疾病，如溶血性贫血，心律失常和神经系统疾病的锚蛋白功能障碍的讨论。
In eukaryotic cells, ankyrins serve as adaptor proteins that link membrane proteins to the underlying cytoskeleton. These adaptor proteins form protein complexes consisting of integral membrane proteins, signalling molecules and cytoskeletal components. With their modular architecture and ability to interact with many proteins, ankyrins organize and stabilize these protein networks, thereby establishing the infrastructure of membrane domains with specialized functions. To this end, ankyrin collaborates with a number of proteins including cytoskeletal proteins, cell adhesion molecules and large structural proteins. This review addresses the targeting and stabilization of protein networks related to ankyrin interactions with the cytoskeletal protein β-spectrin, L1-cell adhesion molecules and the large myofibrillar protein obscurin. The significance of these interactions for differential targeting of cardiac proteins and neuronal membrane formation is also presented. Finally, this review concludes with a discussion about ankyrin dysfunction in human diseases such as haemolytic anaemia, cardiac arrhythmia and neurological disorders.