HUMAN ESTROGEN-RECEPTOR CDNA - SEQUENCE, EXPRESSION AND HOMOLOGY TO V-ERB-A
HUMAN ESTROGEN-RECEPTOR CDNA - SEQUENCE, EXPRESSION AND HOMOLOGY TO V-ERB-A
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DOI：
10.1038/320134a0
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发表时间：
1986-03-13
期刊：
影响因子：
64.8
通讯作者：
CHAMBON, P
中科院分区：
文献类型：
--
作者：
GREEN, S;WALTER, P;CHAMBON, P
我们已经克隆并测序了乳腺癌细胞系MCF-7中雌激素受体（ER）的完整互补DNA。ER cDNA在HeLa细胞中的表达产生了一种蛋白质，该蛋白质具有与MCF-7 ER相同的相对分子质量并以相同的亲和力结合雌二醇。ER和致癌性禽成红细胞增多症病毒的erb-A蛋白之间存在广泛的同源性。
We have cloned and sequenced the complete complementary DNA of the oestrogen receptor (ER) present in the breast cancer cell line MCF-7. The expression of the ER cDNA in HeLa cells produces a protein that has the same relative molecular mass and binds oestradiol with the same affinity as the MCF-7 ER. There is extensive homology between the ER and the erb-A protein of the oncogenic avian erythroblastosis virus.