Protective effects of S-2-(3-aminopropylamino)ethylphosphorothioic acid against radiation damage of normal tissues and a fibrosarcoma in mice.
Protective effects of S-2-(3-aminopropylamino)ethylphosphorothioic acid against radiation damage of normal tissues and a fibrosarcoma in mice.
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发表时间：
1982-05
期刊：
影响因子：
11.2
通讯作者：
L. Milas;N. Hunter;B. Reid;H. Thames
中科院分区：
文献类型：
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作者：
L. Milas;N. Hunter;B. Reid;H. Thames
研究了S-2-（3-氨基丙基氨基）乙基硫代磷酸（WR-2721）对C3 Hf/Kam小鼠空肠、睾丸、肺、毛囊和纤维肉瘤辐射损伤的保护作用。这些组织中的大多数是放射保护的，并且放射保护的程度取决于WR-2721的剂量和WR-2721给药与放射治疗之间的时间间隔。WR-2721使空肠上皮细胞和生精细胞对单剂量γ射线的抵抗力分别增加1.64和1.54倍。对脱发的保护作用不太明显;此处的剂量调整因子为1.24。在放射前用WR-2721处理动物并没有减少由肺中肿瘤结节形成增加所表示的放射诱导的肺急性损伤。与此相反，WR-2721增强了放射诱导的肺转移形成的增强。WR-2721保护肺纤维肉瘤微转移免受辐射治疗效果的影响为1.238倍。相比之下，这种化合物对小鼠腿部生长的8 mm纤维肉瘤的治疗没有影响。
S-2-(3-Aminopropylamino)ethylphosphorothioic acid (WR-2721) was investigated for its protective effect against radiation-produced damage of jejunum, testis, lung, hair follicles, and a fibrosarcoma of C3Hf/Kam mice. Most of these tissues were radioprotected, and the degree of radioprotection depended on the dose of WR-2721 and the time interval between administration of WR-2721 and radiation treatment. WR-2721 increased resistance of jejunal epithelial cells and spermatogenic cells to single doses of gamma-rays by factors of 1.64 and 1.54, respectively. Protection against hair loss was less pronounced; the dose-modifying factor here was 1.24. The radiation-induced acute damage of the lung expressed by the increased formation of tumor nodules in the lung was not decreased by treatment of animals with WR-2721 before radiation. In contrast, WR-2721 augmented the radiation-induced enhancement of metastasis formation in the lung. WR-2721 protected fibrosarcoma micrometastases in the lung against therapeutic effect of radiation by a factor of 1.238. In contrast, this compound had no effect on the therapy of an 8-mm fibrosarcoma growing in the legs of mice.