Paradoxical heat sensation in patients with multiple sclerosis - Evidence for a supraspinal integration of temperature sensation
Paradoxical heat sensation in patients with multiple sclerosis - Evidence for a supraspinal integration of temperature sensation
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DOI：
10.1093/brain/119.5.1729
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发表时间：
1996-10-01
期刊：
影响因子：
14.5
通讯作者：
Treede, RD
中科院分区：
文献类型：
--
作者：
Hansen, C;Hopf, HC;Treede, RD
温度阈值确定在16例可能或明确的多发性硬化症，在6例可能的，但未经证实的多发性硬化症和34名健康受试者，使用的方法的限制和热感觉阈值（TSL）的MarStock技术。一个显着比例的患者的阈值以外的2.5 SD范围正常受试者，无论是温暖的检测阈值和TSL。此外，10例可能或明确的多发性硬化症患者和1例可能的多发性硬化症患者报告了反常的热感觉，即由冷刺激引起的温暖感觉。这种错觉几乎完全是在TSL程序的冷热交替刺激下观察到的。与实验性神经阻滞或周围脱髓鞘性神经病不同，在多发性硬化症患者中，脱髓鞘部位位于中枢神经系统。多发性硬化症患者除了阈值异常外还有反常的热感觉，这一观察结果支持了脊髓上部位对温度感觉的整合很重要的观点。
Temperature thresholds were determined in 16 patients with probable or definite multiple sclerosis, in six patients with possible but unconfirmed multiple sclerosis and in 34 healthy subjects, using the method of limits and the thermal sensory limen (TSL) of the MarStock technique. A significant proportion of the patients had thresholds outside the 2.5 SD range for normal subjects, both for warmth detection threshold and TSL. In addition, 10 patients with probable or definite multiple sclerosis and one patient with possible multiple sclerosis reported a paradoxical heat sensation, i.e. a sensation of warmth elicited by a cold stimulus. This illusion was almost exclusively observed with the alternating warm and cold stimuli of the TSL procedure. In contrast to experimental nerve block or peripheral demyelinating neuropathy, where paradoxical heat sensation has been described by various authors, in the patients with multiple sclerosis the demyelination sites were located in the central nervous system. The observation that multiple sclerosis patients had paradoxical heat sensation in addition to threshold abnormalities supports the view that supraspinal sites are important for the integration of temperature sensation.