IMPAIRMENT OF THE BLOOD-BRAIN-BARRIER AS AN ETIOLOGICAL FACTOR IN PARANOID PSYCHOSIS
IMPAIRMENT OF THE BLOOD-BRAIN-BARRIER AS AN ETIOLOGICAL FACTOR IN PARANOID PSYCHOSIS
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DOI：
10.1192/bjp.141.3.273
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发表时间：
1982-01-01
影响因子：
10.5
通讯作者：
ALLING, C
中科院分区：
文献类型：
--
作者：
AXELSSON, R;MARTENSSON, E;ALLING, C
本文研究了25例偏执型精神病患者血脑屏障损伤可能对精神病学的影响。脑脊液白蛋白浓度与血清白蛋白浓度之比测定显示，7例患者血脑屏障受损，18例患者正常。比较两组患者的临床、药代动力学、神经生理和记忆指标。有血脑屏障损伤的患者比无血脑屏障损伤的患者平均早20年出现精神病，这一非常重要的发现表明，这种损伤可能会影响易感个体精神病的发展。
Possible psychiatric implications of impairment of the blood-brain barrier were studied in 25 patients with paranoid psychosis. Determination of the ratio between the albumin concentratins in CSF and serum showed increases, indicating impairment of the blood-brain barrier, in 7 patients and normal values in 18. The 2 groups were compared for clinical, pharmacokinetics of thioridazine, neurophysiological and anamnestic variables. The highly significant finding that onset of psychosis had occurred, on average, 20 yr earlier in the patients with impairment of the blood-brain barrier than in those without suggests that such impairment might influence the development of psychosis in predisposed individuals.