Use of 99mTc-bicisate in activation studies by split-dose technique.
Use of 99mTc-bicisate in activation studies by split-dose technique.
复制标题
通过分次剂量技术在激活研究中使用 99mTc-bicisate。
DOI：
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发表时间：
1994
影响因子：
6.3
通讯作者：
N. Lassen
中科院分区：
文献类型：
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作者：
S. Holm;P. Madsen;B. Sperling;N. Lassen
大脑单光子发射计算机断层扫描 (SPECT) 示踪剂 99mTc-bicisate（半胱氨酸乙酯二聚体）的特性经过检查，用于短间隔、分剂量研究的重测研究。这些测试中应用的刺激是“闪烁棋盘”图案的视觉激活。我们使用快速动态 SPECT (Tomomatic 232) 记录八个切片。十二名志愿者被分配到两组，分别进行再现性控制和刺激实验。所有人员均在2天内进行了检查。第一天，在静息状态下仅进行一次注射（t = 0），同时进行两次记录（t = 30和t = 100），模拟完整分次剂量研究的过程和时间。 8.3 +/- 1.0% 的平均清除率被用作第二天研究的校正。那天，与第一天一样，在休息时进行了第一次注射，从而可以估计日常的重现性。第二次注射是在与第一次相同的静息状态下进行的，或者是在视觉刺激期间进行的。所有图像均标准化为平均脑计数值。在预定义的感兴趣解剖区域 (ROI) 中分析结果。日常重现性相当，只有一个 ROI（下额皮质）显着下降 2%。第一天的研究揭示了所观察到的冲洗的区域差异，所应用的皮质 ROI 范围为 7.9% 至 11.5%。（摘要截断为 250 字）
The properties of the brain single photon emission computed tomography (SPECT) tracer 99mTc-bicisate (ethyl cysteinate dimer) were examined in regard to its use in test-retest studies with short-interval, split-dose studies. The stimulus applied in these tests was a visual activation by a "flickering chessboard" pattern. We used a fast dynamic SPECT (Tomomatic 232) recording eight slices. Twelve volunteers were assigned to two groups for reproducibility control and stimulation experiments, respectively. All were examined on 2 days. On the first day, only one injection was given in the resting state (t = 0), while two recordings were performed (t = 30 and t = 100), simulating the course and timing of a full split-dose study. The average washout of 8.3 +/- 1.0% was used as a correction on the second-day study. On that day the first injection was given during rest exactly as on day 1, allowing an estimate of day-to-day reproducibility. The second injection was made either in a resting state identical to the first or during visual stimulation. All images were normalized to mean brain count value. Results were analyzed in predefined anatomical regions of interest (ROIs). The day-to-day reproducibility was fair, with only one ROI (inferior frontal cortex) showing a significant 2% decrease. The studies of day 1 revealed a regional difference in observed washout ranging in the applied cortical ROIs from 7.9 to 11.5%.(ABSTRACT TRUNCATED AT 250 WORDS)