A retro-Claisen approach to dolabriferol.
A retro-Claisen approach to dolabriferol.
复制标题
多拉非罗的复古克莱森方法。
DOI：
10.1021/ol060347s
复制
发表时间：
2006
期刊：
影响因子：
5.2
通讯作者：
M. Perkins
中科院分区：
文献类型：
--
作者：
T. Lister;M. Perkins
[反应：见正文]通过DBU诱导的、酯形成的逆克莱森方法产生多拉普利醇的受保护前体30。22中所需的直链碳链通过立体选择性的锂羟醛反应合成。使用与（S）-乳酸乙酯衍生的酮13的立体控制的羟醛缩合反应合成必要的醛和酮片段。
[reaction: see text] The protected precursor 30 to dolabriferol was generated by a DBU-induced, ester-forming, retro-Claisen process. The required linear carbon chain present in 22 was synthesized by a stereoselective lithium aldol reaction. The necessary aldehyde and ketone fragments were synthesized using stereocontrolled aldol reactions with the ethyl (S)-lactate derived ketone 13.