A clinicopathological study of autism
A clinicopathological study of autism
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DOI：
10.1093/brain/121.5.889
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发表时间：
1998-05-01
期刊：
影响因子：
14.5
通讯作者：
Lantos, P
中科院分区：
文献类型：
--
作者：
Bailey, A;Luthert, P;Lantos, P
建立了自闭症的神经病理学研究，并对6名自闭症智障受试者的脑组织进行了检查。获得了临床和教育记录，并对死亡前未见过的病例的父母进行了标准化的诊断性访谈，六个大脑中有四个是巨脑，四个病例发现了皮质异常区域，脑干也有发育异常，特别是下橄榄。在所有成人病例中，浦肯野细胞数量均减少，这种减少有时伴有胶质细胞增生症。这些发现并不支持之前关于局限性神经发育异常的说法。他们确实指出大脑皮层可能与自闭症有关。
A neuropathological study of autism was established and brain tissue examined from six mentally handicapped subjects with autism. Clinical and educational records were obtained and standardized diagnostic interviews conducted with the parents of cases not seen before death, Four of the six brains were megalencephalic, and areas of cortical abnormality were identified in four cases, There were also developmental abnormalities of the brainstem, particularly of the inferior olives. Purkinje cell number was reduced in all the adult cases, and this reduction was sometimes accompanied by gliosis. The findings do not support previous claims of localized neurodevelopmental abnormalities. They do point to the likely involvement of the cerebral cortex in autism.