Spatial Resolution Requirements for Accurate Identification of Drivers of Atrial Fibrillation.
Spatial Resolution Requirements for Accurate Identification of Drivers of Atrial Fibrillation.
复制标题
DOI：
10.1161/circep.116.004899
复制
发表时间：
2017-05
期刊：
影响因子：
--
通讯作者：
Ng FS
中科院分区：
文献类型：
--
作者：
Roney CH;Cantwell CD;Bayer JD;Qureshi NA;Lim PB;Tweedy JH;Kanagaratnam P;Peters NS;Vigmond EJ;Ng FS
补充数字内容可在正文中找到。最近的研究已经证明了房颤(AF)潜在的相互矛盾的机制，数据的空间分辨率经常被认为是产生分歧的潜在原因。本研究的目的是调查标测空间分辨率的变化是否会导致对持续性房颤潜在机制的误解。对转子和焦点源进行了模拟，以估计正确识别潜在房颤机制所需的最小记录点数量。研究了不同数据类型(动作电位、单极或双极电信号)和转子稳定性对分辨率要求的影响。我们还利用临床记录和模拟数据确定了临床使用的心内膜导管识别房颤机制的能力。正确识别转子和焦源所需的空间分辨率是心律失常的空间波长(波前之间的距离)的线性函数。电信号数据的转子定位误差大于动作电位数据。对于任何给定的空间分辨率，与曲折轨迹相比，静止转子的识别更加可靠。所有临床高分辨率多极导管都具有足够的分辨率，当放置在转子芯上时，可以准确地检测和跟踪转子，尽管低分辨率的篮式导管很容易被错误检测，并可能错误地识别不存在的转子。房颤数据的空间分辨率可以显著影响对房颤潜在机制的解释。因此，人体房颤数据的解释必须在记录的空间分辨率的背景下进行。
Supplemental Digital Content is available in the text. Recent studies have demonstrated conflicting mechanisms underlying atrial fibrillation (AF), with the spatial resolution of data often cited as a potential reason for the disagreement. The purpose of this study was to investigate whether the variation in spatial resolution of mapping may lead to misinterpretation of the underlying mechanism in persistent AF. Simulations of rotors and focal sources were performed to estimate the minimum number of recording points required to correctly identify the underlying AF mechanism. The effects of different data types (action potentials and unipolar or bipolar electrograms) and rotor stability on resolution requirements were investigated. We also determined the ability of clinically used endocardial catheters to identify AF mechanisms using clinically recorded and simulated data. The spatial resolution required for correct identification of rotors and focal sources is a linear function of spatial wavelength (the distance between wavefronts) of the arrhythmia. Rotor localization errors are larger for electrogram data than for action potential data. Stationary rotors are more reliably identified compared with meandering trajectories, for any given spatial resolution. All clinical high-resolution multipolar catheters are of sufficient resolution to accurately detect and track rotors when placed over the rotor core although the low-resolution basket catheter is prone to false detections and may incorrectly identify rotors that are not present. The spatial resolution of AF data can significantly affect the interpretation of the underlying AF mechanism. Therefore, the interpretation of human AF data must be taken in the context of the spatial resolution of the recordings.