MORPHOMETRIC ANALYSIS OF THE PREFRONTAL CORTEX IN HUNTINGTONS-DISEASE
MORPHOMETRIC ANALYSIS OF THE PREFRONTAL CORTEX IN HUNTINGTONS-DISEASE
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DOI：
10.1212/wnl.41.7.1117
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发表时间：
1991-07-01
期刊：
影响因子：
9.9
通讯作者：
MYERS, RH
中科院分区：
文献类型：
--
作者：
SOTREL, A;PASKEVICH, PA;MYERS, RH
We performed a morphometric analysis of cresyl violet-stained sections from the dorsolateral prefrontal cortex of 81 patients with Huntington's disease (HD) (grades 2, 3, and 4) and 23 age-matched normal controls. We counted large pyramidal neurons, small neurons, astrocytes, oligodendroglia, and microglia under the guidance of a specifically predefined set of morphologic criteria for each cell type and recorded the thickness of each cortical layer. Our results demonstrate a selective and progressive loss of a subset of the large pyramidal neurons in cortical layers III, V, and VI of HD patients, and a decrease in the thickness of the respective cortical laminae. A genetically determined, cell-autonomous degeneration of cortical neurons could constitute the primary pathologic process. However, the loss of only a fraction of pyramidal cells suggests a parallel, or an alternative, possibility of a retrograde degeneration of cortical neurons that project solely, or principally, to the site of primary degeneration in caudate nuclei.
