Comparison of Clinical Outcomes of Oral Erythroleukoplakia Treated with Photodynamic Therapy Using Either Light-Emitting Diode or Laser Light
Comparison of Clinical Outcomes of Oral Erythroleukoplakia Treated with Photodynamic Therapy Using Either Light-Emitting Diode or Laser Light
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DOI：
10.1002/lsm.20841
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发表时间：
2009-11-01
影响因子：
2.4
通讯作者：
Chiang, Chun-Pin
中科院分区：
文献类型：
--
作者：
Yu, Chuan-Hang;Lin, Hung-Pin;Chiang, Chun-Pin
背景和目标：使用635 nm发光二极管（LED）光的局部5-氨基乙酰丙酸介导的光动力疗法（局部ALA-PDT）是口腔疣状增生的有效治疗方式。这项研究测试是否局部ALA-PDT使用LED或激光也是一种有效的治疗方式为口腔erythroleukoplakia（OEL）lesions.Study Design/Materials and Methods：在这个前瞻性的，但非随机研究，20 OEL病变进行了治疗局部ALA-PDT使用635 nm LED光和26 OEL病变进行了治疗局部ALA-PDT使用635 nm激光。结果：20例经LED光治疗的OEL病灶中，完全缓解（CR）17例，部分缓解（PR）3例。17个CR OEL病变平均需要3.7（范围，2-7）次ALA-PDT治疗才能实现病变CR。26例激光治疗的OEL病变中，25例CR，1例PR。25个CR OEL病变平均需要3.3（范围，2-6）次ALA-PDT治疗才能实现病变CR。20例LED光治疗和26例激光治疗的OEL病变之间的PDT结果无显著差异（P = 0.303）。将42个CR OEL病灶合并在一起，我们发现较小的病灶（最大直径< 1.5 cm）和表面角蛋白（角蛋白层）较薄的病灶
Background and Objectives: Topical 5-aminolevulinic acid-mediated photodynamic therapy (topical ALA-PDT) using a 635-nm light-emitting diode (LED) light is an effective treatment modality for oral verrucous hyperplasia. This study tested whether topical ALA-PDT using either the LED or laser light was also an effective treatment modality for oral erythroleukoplakia (OEL) lesions.Study Design/Materials and Methods: In this prospective but non-randomized study, 20 OEL lesions were treated with topical ALA-PDT using the 635-nm LED light and 26 OEL lesions were treated with topical ALA-PDT using the 635-nm laser light. The difference in clinical outcomes was compared between the two groups by Fisher exact test.Results: We found that the 20 LED light-treated OEL lesions showed complete response (CR) in 17 and partial response (PR) in 3. The 17 CR OEL lesions required an average of 3.7 (range, 2-7) treatments of ALA-PDT to achieve CR of the lesions. The 26 laser light-treated OEL lesions showed CR in 25 and PR in 1. The 25 CR OEL lesions needed an average of 3.3 (range, 2-6) treatments of ALA-PDT to achieve CR of the lesions. There was no significant difference in PDT outcomes between the 20 LED light-treated and 26 laser light-treated OEL lesions (P = 0.303). When the 42 CR OEL lesions were pooled together, we found that smaller lesions (greatest diameter < 1.5 cm) and lesions with thinner surface keratin (keratin layer