Alternative splicing and protein interaction data sets.
Alternative splicing and protein interaction data sets.
复制标题
选择性剪接和蛋白质相互作用数据集。
DOI：
10.1038/nbt.2540
复制
发表时间：
2013
影响因子：
46.9
通讯作者：
Talavera D
中科院分区：
文献类型：
--
作者：
Talavera D
许多目前的方法已经专注于特定的异构体，所以对于这些方法，所使用的异构体总是已知的。然而，公开信息的方式造成了不必要的混乱，并导致对PPI数量的低估。因此，我们主张改变PPI信息公开的方式。由于PPI发生在特定的异构体之间，因此对基础和医学研究的推进至关重要的是，在异构体对异构体的基础上报告相互作用，并且数据库切换到类似的方法。我们预计这样的新平台对实验和计算生物学家来说将是非常有价值的。
Many current methods are already focused on specific isoforms, so for these methods, the isoform used is always known. However, the way in which the information is made publicly available introduces unnecessary confusion and causes underestimation of the number of PPIs. We therefore advocate changes to the way PPI information is made publicly available. Because PPIs occur between particular isoforms, it is crucial to the advance of basic and medical research that interactions are reported on an isoform-to-isoform basis and that databases switch to a similar approach. We anticipate that such new platforms will be extremely valuable to experimental and computational biologists.