Hypothalamic neuronal circuits regulating hunger-induced taste modification
Hypothalamic neuronal circuits regulating hunger-induced taste modification
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DOI：
10.1038/s41467-019-12478-x
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发表时间：
2019-10-08
影响因子：
16.6
通讯作者：
Nakajima, Ken-ichiro
中科院分区：
文献类型：
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作者：
Fu, Ou;Iwai, Yuu;Nakajima, Ken-ichiro
味觉系统在感知食欲和厌恶性味觉刺激以评价食物质量方面起着关键作用。虽然味觉偏好会根据饥饿等内部状态而改变，但其机制仍不清楚。在这里，我们研究神经元机制调节饥饿诱导的味觉修饰。饥饿的小鼠表现出对甜味的偏好和对厌恶味道的耐受性增加。这种饥饿诱导的味觉修饰通过选择性激活下丘脑中的食欲原Agouti相关肽（AgRP）表达神经元来重现，所述神经元投射到外侧下丘脑，但不投射到其他区域。下丘脑外侧部的谷氨酸能神经元（而非GABA能神经元）充当AgRP神经元的下游神经元。重要的是，这些神经元发挥了关键作用，在调节偏好的食欲和厌恶的味道，通过使用不同的途径投射到外侧隔或外侧缰，分别。我们的研究结果表明，这些下丘脑回路将是重要的优化禁食下的摄食行为。
The gustatory system plays a critical role in sensing appetitive and aversive taste stimuli for evaluating food quality. Although taste preference is known to change depending on internal states such as hunger, a mechanistic insight remains unclear. Here, we examine the neuronal mechanisms regulating hunger-induced taste modification. Starved mice exhibit an increased preference for sweetness and tolerance for aversive taste. This hunger-induced taste modification is recapitulated by selective activation of orexigenic Agouti-related peptide (AgRP)expressing neurons in the hypothalamus projecting to the lateral hypothalamus, but not to other regions. Glutamatergic, but not GABAergic, neurons in the lateral hypothalamus function as downstream neurons of AgRP neurons. Importantly, these neurons play a key role in modulating preferences for both appetitive and aversive tastes by using distinct pathways projecting to the lateral septum or the lateral habenula, respectively. Our results suggest that these hypothalamic circuits would be important for optimizing feeding behavior under fasting.