Induction of intestinal metaplasia in the glandular stomach of rats by X-irradiation prior to oral administration of N-methyl-N'-nitro-N-nitrosoguanidine.
Induction of intestinal metaplasia in the glandular stomach of rats by X-irradiation prior to oral administration of N-methyl-N'-nitro-N-nitrosoguanidine.
复制标题
在口服 N-甲基-N-硝基-N-亚硝基胍之前通过 X 射线照射诱导大鼠腺胃肠化生。
DOI：
10.20772/cancersci1959.71.6_804
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
A. Ito
中科院分区：
文献类型：
--
作者：
I. Fujii;H. Watanabe;Y. Terada;Y. Naito;M. Naito;A. Ito
对CD/CRJ大鼠进行胃局部X射线照射，并在饮用水中给予N-甲基-N '-硝基-N-亚硝基胍（MNNG）。单独给予MNNG的大鼠和未处理的大鼠用作对照。在初次给予MNNG后15个月处死时，观察到肠化生;组织学为完全型，X射线和MNNG治疗组大鼠的发生率为100%，而单独给予MNNG治疗组大鼠的肠化生为不完全型，其发生率为80%。然而，仅用MNNG治疗的大鼠的胃癌发生率为25%。
CD/CRJ rats were subjected to localized X-irradiation of the stomach and given N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in the drinking water. Rats given MNNG alone and non-treated rats were used as controls. Upon sacrifice at 15 months after the initial MNNG administration, intestinal metaplasia was observed; the histology was of complete type and the incidence was 100% in rats treated with X-rays and MNNG, whereas in rats treated with MNNG alone the intestinal metaplasia was of incomplete type and its incidence was 80%. However, the incidence of gastric cancer in rats treated with MNNG alone was 25%.