Intermediate filaments regulate astrocyte motility
Intermediate filaments regulate astrocyte motility
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DOI：
10.1046/j.1471-4159.2001.00595.x
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发表时间：
2001-11-01
影响因子：
4.7
通讯作者：
Pekny, M
中科院分区：
文献类型：
--
作者：
Lepekhin, EA;Eliasson, C;Pekny, M
中间丝(IF)与肌动蛋白细丝和微管一起构成细胞骨架，它们表现出一种显著但仍然神秘的细胞类型特异性。在许多类型的细胞中，IF似乎有助于维持细胞和组织的机械完整性。到目前为止，IF在星形胶质细胞中的功能仍然难以捉摸。我们最近报道，在缺乏胶质纤维酸性蛋白和波形蛋白的小鼠中，脑或脊髓损伤后的胶质瘢痕形成受到损害。这些小鼠的反应性星形胶质细胞缺乏F，而星形胶质细胞通常在伤口修复过程中起关键作用。在这里，我们发现缺乏FS的反应性星形胶质细胞表现出明显的形态变化和细胞运动的严重缺陷，从而揭示了IF的一种新功能。
Intermediate filaments (IFs) compose, together with actin filaments and microtubules, the cytoskeleton and they exhibit a remarkable but still enigmatic cell-type specificity. In a number of cell types, IFs seem to be instrumental in the maintenance of the mechanical integrity of cells and tissues. The function of IFs in astrocytes has so far remained elusive. We have recently reported that glial scar formation following brain or spinal cord injury is impaired in mice deficient in glial fibrillary acidic protein and vimentin. These mice lack Fs in reactive astrocytes that are normally pivotal in the wound repair process. Here we show that reactive astrocytes devoid of Fs exhibit clear morphological changes and profound defects in cell motility thereby revealing a novel function for IFs.