Altered expression of COX-2 in subdivisions of the hippocampus during aging and in Alzheimer's disease: The Hisayama study
Altered expression of COX-2 in subdivisions of the hippocampus during aging and in Alzheimer's disease: The Hisayama study
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DOI：
10.1159/000101957
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发表时间：
2007-01-01
影响因子：
2.4
通讯作者：
Iwaki, Toru
中科院分区：
文献类型：
--
作者：
Fujimi, Kouhei;Noda, Kazuhito;Iwaki, Toru
背景：非甾体类抗炎药可延缓阿尔茨海默病（AD）的发病。由于非甾体抗炎药抑制环氧合酶（考克斯），考克斯-2（考克斯的诱导形式）可能与花生四烯酸级联相关地参与AD的病理学。此外，已经表明，多不饱和脂肪酸平衡的改变与脑功能障碍有关，例如老化脑的神经退化性病理学。方法：为了探讨考克斯-2在海马中的表达，我们分析了45例连续尸检的无痴呆的受试者和25例来自日本久山市的AD患者。结果如下：考克斯-2在海马CA 3区、下托、内嗅皮层和经内嗅皮层的神经元表达在非痴呆和AD脑中均一致，并且考克斯-2免疫反应性与非痴呆脑中的年龄相关。AD患者海马CA 1区考克斯-2免疫反应阳性神经元增多，且与AD病理严重程度相关。这种相关性在非痴呆受试者中并不明显。结论：这些结果表明，考克斯-2的表达可能是不同的调节之间的细分的海马和升高的考克斯-2的表达在CA 1的AD大脑可能与AD的病理，从而认知功能障碍。版权所有（c）2007 S. Karger AG，巴塞尔。
Background: It has been reported that nonsteroidal anti-inflammatory drugs may delay the onset of Alzheimer's disease ( AD). Since nonsteroidal anti-inflammatory drugs inhibit cyclooxygenase ( COX), COX-2, an inducible form of COX, may be involved in the pathology of AD in association with the arachidonic acid cascade. In addition, it has been suggested that alterations in the balance of polyunsaturated fatty acids are associated with brain dysfunctions such as neurodegerative pathologies of the aging brain. Method: To explore COX-2 expression in the hippocampus, we analyzed 45 consecutive autopsy subjects without dementia and 25 AD patients derived from the town of Hisayama, Japan. Results: The neuronal expression of COX-2 in the CA3 subdivision of the hippocampus, subiculum, entorhinal cortex and transentorhinal cortex were consistently observed in both nondemented and AD brains, and COX-2 immunoreactivity correlated with age in nondemented brains. In AD patients, neurons of CA1 exhibited increased COX-2 immunoreactivity which correlated with the severity of AD pathology. This correlation was not apparent in nondemented subjects. Conclusion: These results suggest that COX-2 expression may be differentially regulated among subdivisions of the hippocampus and that elevated COX-2 expression in the CA1 of AD brains may be associated with AD pathology and thus cognitive dysfunction. Copyright (c) 2007 S. Karger AG, Basel.