Plasmonic nanoparticle-generated photothermal bubbles and their biomedical applications.
Plasmonic nanoparticle-generated photothermal bubbles and their biomedical applications.
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DOI：
10.2217/nnm.09.59
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发表时间：
2009-10
期刊：
影响因子：
--
通讯作者：
Lapotko D
中科院分区：
文献类型：
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作者：
Lapotko D
本文主要研究等离子体纳米粒子周围光热蒸汽气泡的光学产生和探测。我们报道了这种等离子体纳米气泡的物理性质及其作为细胞探针的生物医学应用。我们对金纳米粒子产生的光热气泡的实验研究表明，光热气泡的产生具有选择性，光散射放大和隔热效应都是在纳米尺度上实现的。活细胞(白血病、癌细胞培养和原代癌细胞)和组织(动物的动脉粥样硬化斑块和实体瘤)中光热气泡的产生和成像表明，通过小的光热气泡对靶细胞进行非侵入性的高灵敏成像，以及由于细胞膜的快速破坏而导致较大的光热气泡对单个靶细胞的选择性机械、非热损伤。对等离子体纳米气泡的分析表明，它们是无缝隙探针，可以在一个快速过程中在细胞水平上进行调谐和光学引导，从诊断到交付和治疗。
This article is focused on the optical generation and detection of photothermal vapor bubbles around plasmonic nanoparticles. We report physical properties of such plasmonic nanobubbles and their biomedical applications as cellular probes. Our experimental studies of gold nanoparticle-generated photothermal bubbles demonstrated the selectivity of photothermal bubble generation, amplification of optical scattering and thermal insulation effect, all realized at the nanoscale. The generation and imaging of photothermal bubbles in living cells (leukemia and carcinoma culture and primary cancerous cells), and tissues (atherosclerotic plaque and solid tumor in animal) demonstrated a noninvasive highly sensitive imaging of target cells by small photothermal bubbles and a selective mechanical, nonthermal damage to the individual target cells by bigger photothermal bubbles due to a rapid disruption of cellular membranes. The analysis of the plasmonic nanobubbles suggests them as theranostic probes, which can be tuned and optically guided at cell level from diagnosis to delivery and therapy during one fast process.