Cumulative Chemical Exposures During Pregnancy and Early Development.
Cumulative Chemical Exposures During Pregnancy and Early Development.
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DOI：
10.1007/s40572-015-0064-x
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发表时间：
2015-12
影响因子：
7.9
通讯作者：
Zota AR
中科院分区：
文献类型：
--
作者：
Mitro SD;Johnson T;Zota AR
工业和消费品化学品被广泛使用，导致人类普遍接触最常见的类别。由于这些化学物质可能影响发育里程碑，孕妇和发育中的胎儿的暴露特别令人关注。在这篇综述中，我们讨论了孕妇化学品暴露的流行情况，母体和胎儿暴露之间的化学品类别特定关系，以及六种化学品类别的主要暴露来源：邻苯二甲酸酯，苯酚，全氟化合物（PFC），阻燃剂，多氯联苯（PCB）和有机氯农药（OC）。此外，我们描述了目前的努力，以表征累积暴露于合成化学品在怀孕期间。最后，我们强调了文献中的差距，并讨论了可能的应用研究结果，以减少怀孕期间累积暴露的患病率。
Industrial and consumer product chemicals are widely used, leading to ubiquitous human exposure to the most common classes. Because these chemicals may affect developmental milestones, exposures in pregnant women and developing fetuses are of particular interest. In this review, we discuss the prevalence of chemical exposures in pregnant women, the chemical class-specific relationships between maternal and fetal exposures, and the major sources of exposures for six chemical classes of concern: phthalates, phenols, perfluorinated compounds (PFCs), flame retardants, polychlorinated biphenyls (PCBs), and organochlorine pesticides (OCs). Additionally, we describe the current efforts to characterize cumulative exposures to synthetic chemicals during pregnancy. We conclude by highlighting gaps in the literature and discussing possible applications of the findings to reduce the prevalence of cumulative exposures during pregnancy.