Delineating the Macroscale Areal Organization of the Macaque Cortex In Vivo
Delineating the Macroscale Areal Organization of the Macaque Cortex In Vivo
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DOI：
10.1016/j.celrep.2018.03.049
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发表时间：
2018-04-10
期刊：
影响因子：
8.8
通讯作者：
Milham, Michael P.
中科院分区：
文献类型：
--
作者：
Xu, Ting;Falchier, Arnaud;Milham, Michael P.
作为对以组织学为中心的长期传统的补充，功能磁共振成像方法在宏观尺度上描绘脑区域组织方面正在迅速成熟。非人灵长类动物（NHP）为克服转化研究中的关键障碍提供了机会。在这里，我们建立的数据要求，实现可重复的和内部有效的包裹在个人。我们证明，功能边界作为一个功能指纹的个别动物，可以实现麻醉或清醒的条件下（休息，自然观），虽然清醒和麻醉状态之间的差异排除了检测的个体差异跨国家。清醒状态和麻醉状态的比较表明，高阶关联区域以及视觉和运动皮层的连接变化更为微妙。这些结果建立的可行性和数据的要求，在NHP的可重复的个人特定的包裹生成，提供洞察扫描状态的影响，并激励努力协调协议。
Complementing long-standing traditions centered on histology, fMRI approaches are rapidly maturing in delineating brain areal organization at the macroscale. The non-human primate (NHP) provides the opportunity to overcome critical barriers in translational research. Here, we establish the data requirements for achieving reproducible and internally valid parcellations in individuals. We demonstrate that functional boundaries serve as a functional fingerprint of the individual animals and can be achieved under anesthesia or awake conditions (rest, naturalistic viewing), though differences between awake and anesthetized states precluded the detection of individual differences across states. Comparison of awake and anesthetized states suggested a more nuanced picture of changes in connectivity for higher-order association areas, as well as visual and motor cortex. These results establish feasibility and data requirements for the generation of reproducible individual-specific parcellations in NHPs, provide insights into the impact of scan state, and motivate efforts toward harmonizing protocols.