Inhibitory effects of fluvastain and its metabolites on the formation of several reactive oxygen species.
Inhibitory effects of fluvastain and its metabolites on the formation of several reactive oxygen species.
复制标题
氟伐他汀及其代谢物对几种活性氧形成的抑制作用。
DOI：
10.1016/s0024-3205(01)01223-1
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发表时间：
2001
期刊：
影响因子：
6.1
通讯作者：
K. Nakashima
中科院分区：
文献类型：
--
作者：
A. Nakashima;M. Ohtawa;K. Iwasaki;M. Wada;N. Kuroda;K. Nakashima
我们研究了氟伐他汀（FV）及其代谢产物（M-2、M-3、M-4、M-5和M-7）对几种活性氧（ROS）形成的抑制作用，如单线态氧（1 O2）、超氧阴离子（O2−）、羟基自由基（.OH）、次氯酸根离子（OCL−）和过氧化亚油酸（LOO.）。同时测定普伐他汀（PV）、辛伐他汀（SV）、普罗布考（PR）和α-生育酚（TOC）的抑制作用。5-hydroxyFV（M-2）和6-hydroxyFV（M-3）对1 O2、O2-、.OH和OCL-生成的抑制作用最强。还观察到M-4、M-5、（+）-FV和（−）-FV对1 O2的清除作用。（+）-FV对1 O2形成的抑制作用与（-）-FV相当。PV、SV、PR和M-7对几种活性氧的形成几乎没有抑制作用。总之，FV及其代谢产物，特别是M-2和M-3，具有保护免受几种ROS介导的氧化应激的潜力。
We investigated the inhibitory effects of fluvastain (FV) and its metabolites (M-2, M-3, M-4, M-5, and M-7) on the formation of several reactive oxygen species (ROS), such as singlet oxygen (1O2), superoxide anion (O2−), hydroxy radical (.OH), hypochlorite ion (OCL−, and linoleic acid peroxide (LOO.). Inhibitory effects of pravastatin (PV), simvastatin (SV), probucol (PR) and α-tocopherol (TOC) were also tested. The inhibitory effects of 5-hydroxy FV (M-2) and 6-hydroxy FV (M-3) on the formation of1O2, O2−, .OH, and OCL−were strongest. Scavenging of1O2by M-4, M-5, (+)-FV, and (−)-FV was also noted. The inhibitory effects of (+)-FV on the formation of1O2were comparable to those of (−)-FV. PV, SV, PR and M-7 had little or no inhibitory effect on the formation of several ROS. In conclusion, FV and its metabolites, particulary M-2 and M-3, have the potential to protect against oxidative stress mediated by several ROS.