Transkingdom Interactions Important for the Pathogenesis of Human Viruses.
Transkingdom Interactions Important for the Pathogenesis of Human Viruses.
复制标题
跨界相互作用对人类病毒的发病机制很重要。
DOI：
10.1093/infdis/jiaa735
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Rowe,HannahM
中科院分区：
文献类型：
--
作者：
Nishimoto,Andrew;Wohlgemuth,Nicholas;Rosch,Jason;Schultz-Cherry,Stacey;Cortez,Valerie;Rowe,HannahM
构成哺乳动物宿主微生物组的细菌、真菌和蠕虫物种对健康和疾病具有深远的影响。致病性病毒在感染期间必须与微生物组竞争，并且可能已经进化为利用或逃避微生物组。病毒体和微生物群之间的直接相互作用以及由微生物群引起的免疫调节和组织重塑都以宿主或病毒有益的方式改变病毒发病机制。最近对病毒发病机制的体外和鼠模型的认识突出了微生物组和致病病毒之间的协同和拮抗、直接和间接相互作用。本综述将重点关注人类胃肠道和呼吸道病毒与这些组织的组成微生物组之间的跨王国相互作用。
The bacterial, fungal, and helminthic species that comprise the microbiome of the mammalian host have profound effects on health and disease. Pathogenic viruses must contend with the microbiome during infection and likely have evolved to exploit or evade the microbiome. Both direct interactions between the virions and the microbiota and immunomodulation and tissue remodeling caused by the microbiome alter viral pathogenesis in either host- or virus-beneficial ways. Recent insights from in vitro and murine models of viral pathogenesis have highlighted synergistic and antagonistic, direct and indirect interactions between the microbiome and pathogenic viruses. This review will focus on the transkingdom interactions between human gastrointestinal and respiratory viruses and the constituent microbiome of those tissues.