Transgelin: An actin-binding protein and tumour suppressor
Transgelin: An actin-binding protein and tumour suppressor
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DOI：
10.1016/j.biocel.2008.02.011
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发表时间：
2009-03-01
影响因子：
4
通讯作者：
Prasad, Priya D.
中科院分区：
文献类型：
--
作者：
Assinder, Stephen J.;Stanton, Jo-Ann L.;Prasad, Priya D.
Transgelin是钙调蛋白家族的一种形状变化敏感的22 kDa肌动蛋白结合蛋白。它包含一个C-末端钙调蛋白样模块（CLIK '-）和一个上游带正电荷的肌动蛋白结合所需的氨基酸区域。Transgelin在血管和内脏平滑肌中普遍存在，并且是平滑肌分化的早期标志物，其中其表达由CArG盒驱动。平滑肌基因启动子它也存在于成纤维细胞和一些上皮细胞中，其中表达可能由TGF-β 1驱动。Transgelin敲除小鼠揭示，虽然它不是平滑肌发育所必需的，但transgelin可能参与钙非依赖性平滑肌收缩。最近的证据表明，transgelin作为一种肿瘤抑制剂。它的表达在前列腺癌、乳腺癌和结肠癌中丢失。这与transgelin对金属基质蛋白酶-9（MMP-9）的抑制一致，其中MMP-9在这些常见癌症中上调。(C)2008爱思唯尔有限公司保留所有权利。
Transgelin is a shape change sensitive 22 kDa actin-binding protein of the calponin family. It contains a C-terminal calponin-like module (CLIK'-;) and an upstream positively charged amino acid region required for actin binding. Transgelin is ubiquitous to vascular and visceral smooth muscle and is an early marker of smooth muscle differentiation, where its expression is driven by CArG box. smooth muscle gene promoter. It is also present in fibroblasts, and some epithelium where expression is likely driven by TGF-beta 1. Transgelin null mice reveal that, whilst it is not required for smooth muscle development, transgelin may be involved in calcium-independent smooth muscle contraction. Recent evidence suggests that transgelin acts as a tumour suppressor. Its expression is lost in prostate, breast and colon cancers. This is consistent with suppression of the metallo matrix protease-9 (MMP-9) by transgelin, where MMP-9 is upregulated in these common cancers. (C) 2008 Elsevier Ltd. All rights reserved.