C2-symmetric bisprolinamide as a highly efficient catalyst for direct aldol reaction
C2-symmetric bisprolinamide as a highly efficient catalyst for direct aldol reaction
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DOI：
10.1021/ol052277f
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发表时间：
2005-11-10
期刊：
影响因子：
5.2
通讯作者：
Zhao, CG
中科院分区：
文献类型：
--
作者：
Samanta, S;Liu, JY;Zhao, CG
脯氨酰胺型催化剂的催化活性可以通过将额外的脯氨酰胺部分引入催化剂中来改善，同时对映选择性仍然可以保持或进一步改善。具有两个脯氨酰胺部分的C-2-对称的双脯氨酰胺已被发现是用于直接羟醛缩合反应的优异催化剂，其反应性比其单脯氨酰胺对应物高一倍以上，并且具有更好的不对称诱导。
The catalytic activity of the prolinamide-type catalysts may be improved by introducing additional prolinamide moiety into the catalyst, while the enantioselectivity can still be maintained or further improved. A C-2-symmetric bisprolinamide with two prolinamide moieties has been found to be an excellent catalyst for direct aldol reaction with more than doubled reactivity and better asymmetric induction than its monoprolinamide counterpart.