Prevalence of peripheral arterial disease - results of the Heinz Nixdorf Recall Study
Prevalence of peripheral arterial disease - results of the Heinz Nixdorf Recall Study
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DOI：
10.1007/s10654-006-0015-9
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发表时间：
2006-04-01
影响因子：
13.6
通讯作者：
Erbel, R
中科院分区：
文献类型：
--
作者：
Kroger, K;Stang, A;Erbel, R
背景：本报告提出了基于人群的外周动脉疾病（PAD）、慢性重度肢体缺血（CLI）和Moenckeberg's medial calcinosis （MC）在德国的患病率估计。患者与方法：2000 - 2003年共纳入4814名年龄在45-75岁之间的受试者。在30名受试者（0.6%）中，无法测定踝肱指数（ABI），数据集中剩下4,735名受试者（99.4%）。所有单腿ABI < 0.9和/或既往有PAD治疗史的受试者均被认为存在PAD。如果最高踝动脉压测量值< 70 mmHg，则认为存在CLI。以ABI临界值为1.3和1.5计算MC患病率。结果：根据ABI标准，PAD的总体患病率在男性中为6.4%，在女性中为5.1%。考虑到PAD病史后，男性患病率上升至8.2%，女性患病率上升至5.5%。将ABI标准和病史考虑在内，男性PAD患病率较高，65-69岁和70-75岁男性患病率增加较多。慢性CLI在调查人群中很少见，仅在5名老年受试者中发现（0.1%）。以ABI b> 1.3为标准，约有13.3%的男性和6.9%的女性患有MC。与PAD相比，MC的患病率不随年龄增长而增加。以ABI >.5为标准，MC分别存在于1.1%和0.5%的男性和女性中，但只有30名（0.6%）受试者踝关节动脉不可压缩，袖带压力>260 mmHg。结论：在基于人群的研究中，仅基于ABI的PAD患病率通常低估了PAD的真实患病率。CLI主要影响老年受试者。此外，MC的临界值必须重新确定。
Background: This report presents population-based estimates of the prevalence of peripheral arterial disease (PAD), chronic critical limb ischemia (CLI), and Moenckeberg's medial calcinosis (MC) in Germany. Patients and methods: From the year 2000 to 2003, a total of 4,814 subjects aged 45-75 years were included in the study. In 30 of the subjects (0.6%), determination of the ankle brachial index (ABI) was not possible, leaving 4,735 subjects (99.4%) in the data set. PAD was considered present in all subjects with an ABI < 0.9 in one leg, and/or a history of prior treatment for PAD. CLI was considered present if the highest ankle artery pressure measured < 70 mmHg. Prevalence of MC was calculated for ABI cut-off values of 1.3 and 1.5. Findings: The overall prevalence of PAD according to the ABI criteria was 6.4% among men and 5.1% among women. After accounting for history of PAD, the prevalence increased to 8.2% among men and 5.5% among women. Taking the ABI criteria and medical history into account, males had a higher prevalence of PAD, with large increases in males aged 65-69 and 70-75 years. Chronic CLI was rare in the investigated population, and was found in only five older subjects (0.1%). With the criterion of ABI > 1.3, about 13.3% of males and 6.9% of females had MC. In contrast to PAD, the prevalence of MC did not increase with age. With the criterion of ABI > 1.5, MC was present in only 1.1% and 0.5% of men and women, respectively, but only 30 (0.6%) subjects had incompressible ankle arteries with a cuff pressure > 260 mmHg. Conclusion: Prevalences of PAD based only on ABI generally underestimate the true prevalence of PAD in population-based studies. CLI predominantly affects older subjects. In addition, cut-off values for MC must be newly determined.