An Introduction to Purinergic Receptors
An Introduction to Purinergic Receptors
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嘌呤能受体简介
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
Christine M. Brown
中科院分区：
文献类型：
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作者：
G. Burnstock;Christine M. Brown
腺苷三磷酸（ATP）是细胞内的能量来源。然而，在过去的50年中，嘌呤核苷酸和核苷已被证明对可兴奋膜具有有效的细胞外作用，这可能涉及生理调节过程（Berne，1963; Burnstock，1972，1975，1979; Baer和Drummond，1979）。虽然嘌呤受体的知识仍处于起步阶段相比，大量的工作经典的肾上腺素能和胆碱能受体，正在取得很大的进展，他们的药理学特性，离子的基础上，他们的行动和他们的生化身份。嘌呤能受体领域的历史方面将在下面简要总结，而它们的分布，生理作用和化学的细节将在下面的章节中处理。
Adenosine 5′-triphosphate (ATP) was primarily considered as an intracellular energy source for many years. However, during the past fifty years purine nucleotides and nucleosides have been shown to have potent extracellular actions on excitable membranes which may be involved in physiological regulatory processes (Berne, 1963; Burnstock, 1972, 1975, 1979; Baer and Drummond, 1979). While knowledge of purinergic receptors is still in its infancy compared to the voluminous work on the classical adrenergic and cholinergic receptors, much progress is being made on their pharmacological characterisation, the ionic basis of their actions and their biochemical identity. The historical aspects of the purinergic receptor field will be briefly summarised below, while details of their distribution, physiological roles and chemistry will be dealt with in the chapters which follow.