The link between some alleles on human leukocyte antigen system and autism in children
The link between some alleles on human leukocyte antigen system and autism in children
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DOI：
10.1016/j.jneuroim.2012.10.002
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发表时间：
2013-02-15
影响因子：
3.3
通讯作者：
Al-Ayadhi, Laila Y.
中科院分区：
文献类型：
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作者：
Mostafa, Gehan A.;Shehab, Abeer A.;Al-Ayadhi, Laila Y.
一些自闭症患者脑自身免疫启动的原因还不清楚。某些自身免疫性疾病与人类白细胞抗原（HLA）系统的特定等位基因有关。因此，我们研究了一些HLA-DRB 1等位基因的频率在100名自闭症儿童和100名健康匹配的儿童的差异杂交与序列特异性寡核苷酸探针。研究了获得或缺乏这些等位基因与自闭症之间的关联风险，以及自闭症亲属中自身免疫性疾病的病史。孤独症儿童HLA-DRB 1 *11等位基因频率显著高于对照组（P
The reason behind the initiation of autoimmunity to brain in some patients with autism is not well understood. There is an association between some autoimmune disorders and specific alleles of human leukocyte antigen (HLA) system. Thus, we examined the frequency of some HLA-DRB1 alleles in 100 autistic children and 100 healthy matched-children by differential hybridization with sequence-specific oligonucleotide probes. The risk of association between acquisition or absence of these alleles and autism and also a history of autoimmune diseases in autistic relatives was studied. Autistic children had significantly higher frequency of HLA-DRB1*11 allele than controls (P