Reward circuitry function in autism spectrum disorders
Reward circuitry function in autism spectrum disorders
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DOI：
10.1093/scan/nsq095
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发表时间：
2012-02-01
影响因子：
4.2
通讯作者：
Bodfish, James W.
中科院分区：
文献类型：
--
作者：
Dichter, Gabriel S.;Felder, Jennifer N.;Bodfish, James W.
自闭症谱系障碍（ASD）的社会互动缺陷和限制性重复行为和兴趣可能都反映了大脑奖励回路的异常功能。然而，没有神经影像学研究迄今已调查的完整性奖励电路使用的激励延迟范式与自闭症患者。在本研究中，我们使用功能性磁共振成像来评估15名ASD参与者和16名匹配的对照参与者在奖励预期和结果期间的血氧水平依赖性激活。大脑激活进行了评估，在预期和响应的金钱激励和对象图像的激励，以前被证明是视觉上突出的个人与ASD（如火车，电子）。自闭症患者在货币预期和结果中表现出减少的丘脑核激活，但在对象预期或结果中则没有。X组奖励类型互动测试显示，在奖励预期和奖励结果的腹内侧前额叶皮层在双边核脑桥强有力的互动效应，表明在这些地区的奖励类型的不同反应。结果表明，ASD的特点是奖励电路hypoactivation响应于金钱的激励，但不是在自闭症相关的对象图像。本文还讨论了ASD患者奖赏回路功能中奖赏类型和时间相双重分离的临床意义。
Social interaction deficits and restricted repetitive behaviors and interests that characterize autism spectrum disorders (ASDs) may both reflect aberrant functioning of brain reward circuits. However, no neuroimaging study to date has investigated the integrity of reward circuits using an incentive delay paradigm in individuals with ASDs. In the present study, we used functional magnetic resonance imaging to assess blood-oxygen level-dependent activation during reward anticipation and outcomes in 15 participants with an ASD and 16 matched control participants. Brain activation was assessed during anticipation of and in response to monetary incentives and object image incentives previously shown to be visually salient for individuals with ASDs (e.g. trains, electronics). Participants with ASDs showed decreased nucleus accumbens activation during monetary anticipation and outcomes, but not during object anticipation or outcomes. Group x reward-type-interaction tests revealed robust interaction effects in bilateral nucleus accumbens during reward anticipation and in ventromedial prefrontal cortex during reward outcomes, indicating differential responses contingent on reward type in these regions. Results suggest that ASDs are characterized by reward-circuitry hypoactivation in response to monetary incentives but not in response to autism-relevant object images. The clinical implications of the double dissociation of reward type and temporal phase in reward circuitry function in ASD are discussed.