Exaggerated fractional sodium excretion in hypertension with advanced renal disease: the role of renal prostaglandin and kallikrein.
Exaggerated fractional sodium excretion in hypertension with advanced renal disease: the role of renal prostaglandin and kallikrein.
复制标题
高血压伴晚期肾病患者钠排泄分数过高：肾前列腺素和激肽释放酶的作用。
DOI：
10.1042/cs061327s
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发表时间：
1981
期刊：
影响因子：
6
通讯作者：
K. Yoshinaga
中科院分区：
文献类型：
--
作者：
K. Abe;Y. Imai;M. Sato;T. Haruyama;K. Sato;M. Hiwatari;Y. Kasai;S. Itoh;M. Yasujima;M. Seino;K. Yoshinaga
1.探讨肾源性前列腺素E(PGE)和激肽释放酶在高血压伴进展性肾病患者部分钠排泄增加机制中的作用。2.持续性高血压患者尿PGE和激肽释放酶排泄量明显减少。3.持续性高血压患者的钠排泄率是对照组的4倍，经内生肌酐清除校正后的前列腺素E尿排泄量是对照组的4-5倍。两者呈显著正相关(r=0.677)，提示肾小管室前列腺素E可能参与了进展期肾病患者部分钠排泄增多的机制。4.与正常人相比，临界高血压患者尿激肽释放酶排泄率增加3倍，而持续性高血压患者尿激肽释放酶排泄率增加不明显。
1. The role of renal prostaglandin E (PGE) and kallikrein in the mechanism of the exaggerated fractional sodium excretion in hypertensive patients with advanced renal disease was investigated. 2. Urinary excretion of PGE and kallikrein was significantly decreased in patients with sustained hypertension. 3. Four times higher values for fractional sodium excretion and four or five times higher values for the urinary excretion of PGE corrected for creatinine clearance were found in patients with sustained hypertension. There was a significant positive correlation (r = 0.677) between the two, suggesting that PGE in the renal tubular compartment may be involved in the mechanism of the exaggerated fractional Na excretion in patients with advanced renal disease. 4. The urinary excretion rate of kallikrein corrected for creatinine clearance was three times greater in patients with borderline hypertension, but not significantly increased in those with sustained hypertension, compared with that in healthy volunteers.