Efferocytosis of dying cells differentially modulate immunological outcomes in tumor microenvironment.
Efferocytosis of dying cells differentially modulate immunological outcomes in tumor microenvironment.
复制标题
DOI：
10.1111/imr.12587
复制
发表时间：
2017-11
影响因子：
8.7
通讯作者：
Birge RB
中科院分区：
文献类型：
--
作者：
Kumar S;Calianese D;Birge RB
程序性细胞死亡（凋亡）是复杂生物体中组织稳态的一个组成部分，允许组织更新、修复和更新，同时抑制自身抗原的释放和凋亡细胞衍生成分的危险信号，这些信号可导致免疫激活、炎症和自身免疫。与培养细胞不同，在体内因细胞凋亡而死亡的细胞的生理命运是它们被吞噬细胞快速识别和吞噬（这一过程称为efferocytosis）。为此，凋亡细胞表达特定的吞噬信号，如外化磷脂酰丝氨酸（PS），这些信号在特定环境下被受体识别，从而启动吞噬的信号通路。在由PS受体和信号分子缺陷引起的炎症和自身免疫性疾病中，仔细调节识别和清除途径的重要性是显而易见的。然而，近年来出现了几种额外的细胞死亡途径，包括免疫原性细胞死亡、坏死性细胞死亡、焦亡和网状细胞死亡，它们交织在不同的细胞死亡途径中，具有典型细胞凋亡的独特先天和适应性反应，可以形成长期的宿主免疫。在这篇综述中，我们讨论了不同的细胞死亡途径在其免疫潜在结果方面的作用，特别是导致特异性细胞尸体/吞噬细胞相互作用（吞噬突触），这些相互作用会影响宿主免疫，主要强调耐受性和癌症免疫治疗。
Programmed cell death (apoptosis) is an integral part of tissue homeostasis in complex organisms, allowing for tissue turnover, repair, and renewal while simultaneously inhibiting the release of self antigens and danger signals from apoptotic cell-derived constituents that can result in immune activation, inflammation, and autoimmunity. Unlike cells in culture, the physiological fate of cells that die by apoptosis in vivo is their rapid recognition and engulfment by phagocytic cells (a process called efferocytosis). To this end, apoptotic cells express specific eat-me signals, such as externalized Phosphatidylserine (PS), that are recognized in a specific context by receptors to initiate signaling pathways for engulfment. The importance of carefully regulated recognition and clearance pathways is evident in the spectrum of inflammatory and autoimmune disorders caused by defects in PS receptors and signaling molecules. However, in recent years, several additional cell death pathways have emerged, including immunogenic cell death, necroptosis, pyroptosis, and netosis, that interweave different cell death pathways with distinct innate and adaptive responses from classical apoptosis that can shape long-term host immunity. In this review, we discuss the role of different cell death pathways in terms of their immune potential outcomes specifically resulting in specific cell corpse/phagocyte interactions (phagocytic synapses) that impinge on host immunity, with a main emphasis on tolerance and cancer immunotherapy.
登录
查看更多内容
DOI：
10.1126/science.aac9935
发表时间：
2016-04-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Casey SC;Tong L;Li Y;Do R;Walz S;Fitzgerald KN;Gouw AM;Baylot V;Gütgemann I;Eilers M;Felsher DW
通讯作者：
Felsher DW
影响因子：
8
作者：
Dong, Y.;Richards, J-A E.;Wajapeyee, N.
通讯作者：
Wajapeyee, N.
抑制磷脂酰丝氨酸识别可增强体内受辐射淋巴瘤细胞的免疫原性。
影响因子：
15.3
作者：
Bondanza, A;Zimmermann, VS;Rovere-Querini, P;Turnay, J;Dumitriu, IE;Stach, CM;Voll, RE;Gaipl, US;Bertling, W;Pöschl, E;Kalden, JR;Manfredi, AA;Herrmann, M
通讯作者：
Herrmann, M
影响因子：
21.3
作者：
Brugnera, E;Haney, L;Ravichandran, KS
通讯作者：
Ravichandran, KS
影响因子：
3.7
作者：
Akakura, S;Sukhwinder, SA;Birge, RB
通讯作者：
Birge, RB