Staphylococcus aureus vs. Osteoblast: Relationship and Consequences in Osteomyelitis.
Staphylococcus aureus vs. Osteoblast: Relationship and Consequences in Osteomyelitis.
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DOI：
10.3389/fcimb.2015.00085
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发表时间：
2015
影响因子：
5.7
通讯作者：
Gangloff SC
中科院分区：
文献类型：
--
作者：
Josse J;Velard F;Gangloff SC
骨细胞，即成骨细胞和破骨细胞协同工作，负责骨细胞外基质的形成和吸收。在金黄色葡萄球菌感染期间，这种动态平衡在一定程度上是通过诱导成骨细胞的各种反应而改变的。这包括过度产生趋化因子、细胞因子和生长因子，因此表明这些细胞在先天免疫和获得性免疫中都发挥了作用。金黄色葡萄球菌通过诱导细胞凋亡依赖和独立的机制降低成骨细胞的活性和存活率。破骨细胞和成骨细胞之间的紧密关系也受到金黄色葡萄球菌感染的调节。本文综述了金黄色葡萄球菌与成骨细胞相互作用的重要方面，以及抗菌肽对成骨细胞内金黄色葡萄球菌的杀伤作用，强调了新的抗感染治疗方法的必要性。
Bone cells, namely osteoblasts and osteoclasts work in concert and are responsible for bone extracellular matrix formation and resorption. This homeostasis is, in part, altered during infections by Staphylococcus aureus through the induction of various responses from the osteoblasts. This includes the over-production of chemokines, cytokines and growth factors, thus suggesting a role for these cells in both innate and adaptive immunity. S. aureus decreases the activity and viability of osteoblasts, by induction of apoptosis-dependent and independent mechanisms. The tight relationship between osteoclasts and osteoblasts is also modulated by S. aureus infection. The present review provides a survey of the relevant literature discussing the important aspects of S. aureus and osteoblast interaction as well as the ability for antimicrobial peptides to kill intra-osteoblastic S. aureus, hence emphasizing the necessity for new anti-infectious therapeutics.