Mucosal vaccines: Strategies and challenges
Mucosal vaccines: Strategies and challenges
复制标题
粘膜疫苗：策略与挑战
DOI：
10.1016/j.imlet.2019.10.013
复制
发表时间：
2020-01-01
影响因子：
4.4
通讯作者：
Qiu, Hua-Ji
中科院分区：
文献类型：
--
作者：
Li, Miao;Wang, Yi;Qiu, Hua-Ji
与传统的胃肠外免疫相比，粘膜免疫具有潜在的益处，可以引发粘膜和全身组织的免疫防御，以保护粘膜表面免受病原体入侵。为了在这些入境口岸提供第一线保护，已经开发了粘膜疫苗，并为减少传染病负担带来了重大希望。然而，直到最近，只有有限的粘膜疫苗可用。本文综述了近年来粘膜疫苗的最新研究进展，包括粘膜免疫的适宜给药途径、合理剂型、抗原采集和免疫应答，以及提高粘膜疫苗免疫效果的策略。最后，我们讨论了研制成功的粘膜疫苗所面临的挑战和潜在的解决方案。
Mucosal immunization has potential benefits over conventional parenteral immunization, eliciting immune defense in both mucosal and systemic tissue for protecting from pathogen invasion at mucosal surfaces. To provide a first line of protection at these entry ports, mucosal vaccines have been developed and hold a significant promise for reducing the burden of infectious diseases. However, until very recently, only limited mucosal vaccines are available. This review summarizes recent advances in selected aspects regarding mucosal vaccination, including appropriate administration routes, reasonable formulations, antigen-sampling and immune responses of mucosal immunity, and the strategies used to improve mucosal vaccine efficacy. Finally, the challenges of developing successful mucosal vaccines and the potential solutions are discussed.