Late presentation of esophageal cancer: Observations in a multiracial South-East Asian population
Late presentation of esophageal cancer: Observations in a multiracial South-East Asian population
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DOI：
10.1111/j.1751-2980.2009.00410.x
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发表时间：
2010-02-01
影响因子：
3.5
通讯作者：
Goh, Khean-Lee
中科院分区：
文献类型：
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作者：
Abdullah, Muhammad;Karim, Adil Abdel;Goh, Khean-Lee
目的：食管癌（ECA）是马来西亚的一种重要癌症。本研究的目的是审查人口统计学数据和临床表现的ECA患者看到在马来亚大学医学中心，吉隆坡。方法：组织学证实ECA患者被招募的研究。回顾患者的病例记录、内窥镜检查和手术室记录。结果：1998年至2003年间，共确诊ECA患者143例。患者的平均年龄为63.1 ± 12.1岁，男性：女性比例为1.8：1。其中50.3%是印度人，32.9%是华人，16.8%是马来人。按种族划分，每100，000例住院患者的总体医院患病率为：马来人; 23.5;华人; 57.4和印度人; 134.1。肿瘤的位置：上; 16（11.2%）中间; 52（36.4%）和下; 75（52.4%）。组织学类型：鳞癌113例（79.0%），腺癌30例（21.0%）。诊断时ECA分期为：II期18例（12.6%），III期23例（16.1%），IV期102例（71.3%）。手术治疗24例（16.8%），治愈13例（9.1%）。总的来说，114例（79.7%）患者接受姑息性内镜支架植入术和6例（4.2%）给予其他姑息性治疗，包括放疗。ECA在我们的患者中出现较晚，只有少数患者接受了根治性手术。
OBJECTIVE:Esophageal cancer (ECA) is an important cancer in Malaysia. The aim of the study is to review the demographic data and clinical presentation of patients with ECA seen at the University of Malaya Medical Centre, Kuala Lumpur.METHODS:Patients with histologically proven ECA were recruited for the study. Patients' case notes, endoscopy and operating theater records were reviewed. All cases were histologically confirmed.RESULTS:A total of 143 patients with ECA was diagnosed between 1998 and 2003. The mean age of the patients was 63.1 +/- 12.1 years with a male : female ratio of 1.8:1. Of these 50.3 percent were Indians, 32.9 percent, Chinese and 16.8 percent Malays. The overall hospital-based prevalence rates per 100 000 admissions according to races were: Malay; 23.5, Chinese; 57.4 and Indian; 134.1. The location of the tumors was: upper; 16 (11.2%) middle; 52 (36.4%) and lower; 75 (52.4%). The histological type of ECA were: squamous cell carcinomas; 113 (79.0%) and adenocarcinomas; 30 (21.0%). The ECA stage at diagnosis, was: II; 18 (12.6%), III; 23 (16.1%) and IV; 102 (71.3%). Only 24 (16.8%) patients underwent surgery and13 (9.1%) were considered curative. Overall 114 (79.7%) patients underwent palliative endoscopic stenting and six (4.2%) were given other palliative therapy including radiotherapy.CONCLUSIONS:Squamous cell cancer was the predominant type. ECA presents late in our patients and only a minority of patients underwent curative surgery.