What do drug transporters really do?
What do drug transporters really do?
复制标题
DOI：
10.1038/nrd4461
复制
发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Nigam SK
中科院分区：
文献类型：
--
作者：
Nigam SK
由三磷酸腺苷结合盒(ABC)转运体和溶质载体(SLC)转运体家族介导的潜在的药物相互作用是临床和监管关注的问题。然而，这些药物转运体的内源性功能还不是很清楚。这里讨论的是ABC和SLC转运蛋白在处理不同底物中的作用的证据，包括代谢物、抗氧化剂、信号分子、激素、营养物质和神经递质。有人提出，这些转运体可能是细胞、器官、体液隔间，甚至可能是独立的生物体之间更大的远程通信(‘遥感和信号’)系统的一部分。这一更广泛的观点可能有助于阐明与糖尿病、慢性肾脏疾病、代谢综合征、高血压、痛风、肝脏疾病、神经精神障碍、炎症综合征和器官损伤以及产前和出生后发育有关的疾病机制、药物-代谢物相互作用和药物效应。
Potential drug–drug interactions mediated by the ATP-binding cassette (ABC) transporter and solute carrier (SLC) transporter families are of clinical and regulatory concern. However, the endogenous functions of these drug transporters are not well understood. Discussed here is evidence for the roles of ABC and SLC transporters in the handling of diverse substrates, including metabolites, antioxidants, signalling molecules, hormones, nutrients and neurotransmitters. It is suggested that these transporters may be part of a larger system of remote communication (‘remote sensing and signalling’) between cells, organs, body fluid compartments and perhaps even separate organisms. This broader view may help to clarify disease mechanisms, drug–metabolite interactions and drug effects relevant to diabetes, chronic kidney disease, metabolic syndrome, hypertension, gout, liver disease, neuropsychiatric disorders, inflammatory syndromes and organ injury, as well as prenatal and postnatal development.