Renal and Extrarenal Erythropoietin Production in Anaemic Rats
Renal and Extrarenal Erythropoietin Production in Anaemic Rats
复制标题
贫血大鼠肾内和肾外促红细胞生成素的产生
DOI：
10.1111/j.1365-2141.1980.tb03811.x
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发表时间：
1980
影响因子：
6.5
通讯作者：
R. Silver
中科院分区：
文献类型：
--
作者：
A. Erslev;J. Caro;E. Kansu;R. Silver
总结。通过单次出血或单次注射苯肼造成大鼠贫血。在贫血发生后的不同时间，他们被切除肾脏，并暴露在6h的低氧中。在缺氧期结束时观察到的促红细胞生成素滴度被校正为单独由贫血引起的肾脏促红细胞生成素，并将所产生的肾外成分与肾脏大鼠在贫血加缺氧6小时的反应中产生的总促红细胞生成素进行比较。肾外促红细胞生成素的产生由正常大鼠的10.3%增加到中度贫血大鼠的12.5%和重度出血性贫血大鼠的15.1%。在苯肼处理的大鼠中，这种肾外成分被发现为18.3%，可能是由于溶血红细胞刺激肾外促红细胞生成素所致。长期服用苯肼可导致脾肿大和库普弗细胞过度活跃，但不会进一步刺激肾外促红细胞生成素的产生。
Summary. Rats were rendered anaemic by a single bleeding or by a single injection of phenylhydrazine. At various times after the onset of anaemia they were nephrec‐tomized and challenged with a 6 h exposure to hypoxia. The erythropoietin titre observed at the end of this hypoxic period was corrected for renal erythropoietin induced by the anaemia alone, and the resulting extrarenal component was compared to total erythropoietin production of nephric rats in response to anaemia plus 6 h hypoxia. Extrarenal erythropoietin production was found to increase from 10.3% in normal rats to 12.5% in moderately anaemic rats to 15.1% in rats with severe bleeding anaemia. In phenylhydrazine‐treated rats this extrarenal component was found to be 18.3% possibly due to stimulation of extrarenal erythropoietin by haemolysed red cells. Chronic phenylhydrazine administration resulted in splenomegaly and Kupffer cell hyperactivity but not in any further stimulation of extrarenal erythropoietin production.