Leaflet Stresses During Full Device Simulation of Crimping to 6 mm in Transcatheter Aortic Valve Implantation, TAVI.
Leaflet Stresses During Full Device Simulation of Crimping to 6 mm in Transcatheter Aortic Valve Implantation, TAVI.
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DOI：
10.1007/s13239-022-00614-6
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发表时间：
2022-10
影响因子：
1.8
通讯作者：
Bressloff, N. W.
中科院分区：
文献类型：
--
作者：
Bressloff, N. W.
关键词：
随着经导管主动脉瓣植入术治疗失败的主动脉瓣的持续增长，人们对人工瓣膜的耐用性和应激对瓣叶的潜在损害越来越感兴趣。虽然大多数现有的利用有限元分析计算预测小叶应力的研究都集中在动态加载过程中的变化，但关于卷曲的影响的报道似乎很少，尽管人们普遍意识到这种影响。潜在地，这是由于进行卷曲到临床上有意义的直径的全模型模拟的困难。一个完整的模型，包括一个自我膨胀的框架，裙子和传单已经开发出来，并卷曲到最终直径6毫米。提供了有限元分析设置的详细说明，强调了成功卷曲到这个小直径所需的裙边定义的重要性。然后，分析了叶折叠和应力，特别是关于叶厚度0.20、0.25和0.30 mm之间的差异以及生物假体和聚合物叶材料模型的差异。在所有病例中，峰值应力发生在连接小叶的模拟缝合线附近，并且沿小叶中轴向排列的褶皱也存在高应力。聚合物小叶的应力较低。卷曲的成功模拟需要精细解析的裙子网格。卷曲过程中的小叶应力取决于小叶厚度、材料特性以及小叶体积与被卷曲阀门内的可用体积的比率。网上版载有补充材料，可在10.1007/s13239-022-00614-6查阅。
With continuing growth in transcatheter aortic valve implantation for the treatment of a failing aortic valve, there is increasing interest in prosthetic valve durability and the potential damage caused to leaflets by stress. Whilst most available research into the computational prediction of leaflet stresses using finite element analysis, FEA, has focussed on variations during dynamic loading, very little appears to have been reported for the impact of crimping, even though awareness of this effect is widespread. Potentially, this has been due to the difficulty of performing full model simulations of crimping to clinically meaningful diameters. A full model comprising a self-expanding frame, skirt and leaflets has been developed and crimped to a final diameter of 6 mm. A detailed description is provided of the FEA setup, emphasising the importance of the skirt definition needed to successfully crimp to this small diameter. Then, an analysis of leaflet folding and stresses is presented, particularly with respect to the differences produced between leaflet thicknesses of 0.20, 0.25 and 0.30 mm and for bioprosthetic and polymeric leaflet material models. In all cases, peak stresses occurred close to the modelled suture lines joining the leaflets and the skirt and high stresses were also present along axially aligned folds in the leaflets. Stresses were lower for the polymeric leaflets. Successful simulation of crimping requires a finely resolved skirt mesh. Leaflet stresses during crimping are dependent on leaflet thickness, material properties and the ratio of leaflet volume to the available volume inside the crimped valve. The online version contains supplementary material available at 10.1007/s13239-022-00614-6.
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影响因子：
4.6
作者：
Alavi, S. Hamed;Groves, Elliott M.;Kheradvar, Arash
通讯作者：
Kheradvar, Arash
DOI：
10.1016/s0045-7825(96)01147-4
发表时间：
1997-04-15
影响因子：
7.2
作者：
Auricchio, F;Taylor, RL
通讯作者：
Taylor, RL
DOI：
10.3390/biomechanics1010004
发表时间：
2021-03-01
期刊：
BIOMECHANICS
影响因子：
--
作者：
Pasta, Salvatore;Gandolfo, Caterina
通讯作者：
Gandolfo, Caterina
影响因子：
2.4
作者：
Bosmans, Bart;Famaey, Nele;Vander Sloten, Jos
通讯作者：
Vander Sloten, Jos
了解TAVR设备的扩展与双质主动脉瓣的形态有关：一项仿真研究。
影响因子：
3.7
作者：
Kusner J;Luraghi G;Khodaee F;Rodriguez Matas JF;Migliavacca F;Edelman ER;Nezami FR
通讯作者：
Nezami FR