The mechanism of betaxolol, a new ocular hypotensive agent.
The mechanism of betaxolol, a new ocular hypotensive agent.
复制标题
新型降眼压药倍他洛尔的作用机制。
DOI：
10.1016/s0161-6420(83)34380-3
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发表时间：
1983
期刊：
影响因子：
13.7
通讯作者：
Brubaker,RF
中科院分区：
文献类型：
--
作者：
Reiss,GR;Brubaker,RF
用1%倍他洛尔眼液对24名正常人进行单滴双盲试验。受试者在一只眼睛上滴一滴这种新药，在另一只眼睛上滴一滴安慰剂。用荧光光度法测定房水流量，用张力描记法测定流出阻力。倍他洛尔抑制所有个体房水血流。抑制范围为7% ~ 51%，平均抑制32±13%。药物对流出阻力无一致性影响，瞳孔未见改变。
A single drop, double-masked study was performed using 1 % betaxolol ophthalmic solution in 24 normal subjects. Subjects received one drop of this new drug to one eye and a placebo drop to the fellow eye. Aqueous humor flow was measured using the technique of fluorophotometry, and outflow resistance was measured using tonography. Betaxolol suppressed aqueous humor flow in all individuals. The range of suppression was from 7 to 51%, with a mean suppression of 32 ± 13%. The drug had no consistent effect on outflow resistance, and no pupillary changes were seen.