Dietary Cadmium Exposure and Risk of Postmenopausal Breast Cancer: A Population-Based Prospective Cohort Study
Dietary Cadmium Exposure and Risk of Postmenopausal Breast Cancer: A Population-Based Prospective Cohort Study
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DOI：
10.1158/0008-5472.can-11-0735
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发表时间：
2012-03-15
期刊：
影响因子：
11.2
通讯作者：
Akesson, Agneta
中科院分区：
文献类型：
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作者：
Julin, Bettina;Wolk, Alicja;Akesson, Agneta
普遍存在的食品污染物镉具有雌激素模拟物的特征，可能促进雌激素依赖性恶性肿瘤的发展，如乳腺癌。然而，没有关于镉暴露和乳腺癌风险的前瞻性研究报告。我们在一个以人群为基础的前瞻性队列中，对55,987名绝经后妇女的饮食镉暴露（基线，1987年）与总体和雌激素受体（ER）定义的（ER+或ER-）乳腺癌风险之间的关系进行了研究。在平均12.2年的随访期间，确定了2，112例浸润性乳腺癌的发病病例（1，626例ER+和290例ER-）。调整混杂因素后，包括全谷物和蔬菜的摄入量（占膳食暴露量的40%，但也含有推定的抗癌植物化学物质），膳食镉摄入量与总体乳腺癌肿瘤呈正相关，比较最高三分位数与最低三分位数[率比（RR），1.21; 95%置信区间（CI），1.07-1.36; P趋势= 0.02]。在瘦体重和正常体重女性中，观察到所有肿瘤（RR，1.27; 95%CI，1.07-1.50）和ER+肿瘤（RR，125; 95%CI，1.03-1.52）的统计学显著相关性，ER-肿瘤（RR，1.22; 95%CI，0.76-1.93）的相关性相似，但无统计学显著性。乳腺癌的风险增加，增加镉暴露类似于每一个纺织品的全谷物/蔬菜消费和减少全谷物/蔬菜的消费量增加，在每个三分位的镉暴露（P-交互= 0.73）。总的来说，这些结果表明饮食镉在绝经后乳腺癌发展中的作用。Cancer Res; 72（6）; 1459-66. (C)2012年AACR
The ubiquitous food contaminant cadmium has features of an estrogen mimetic that may promote the development of estrogen-dependent malignancies, such as breast cancer. However, no prospective studies of cadmium exposure and breast cancer risk have been reported. , We examined the association between dietary cadmium exposure (at baseline, 1987) and the risk of overall and estrogen receptor (ER)-defined (ER+ or ER-) breast cancer within a population-based prospective cohort of 55,987 postmenopausal women. During an average of 12.2 years of follow-up, 2,112 incident cases of invasive breast cancer were ascertained (1,626 ER+ and 290 ER-). After adjusting for confounders, including consumption of whole grains and vegetables (which account for 40% of the dietary exposure, but also contain putative anticarcinogenic phytochemicals), dietary cadmium intake was positively associated with overall breast cancer tumors, comparing the highest tertile with the lowest [rate ratio (RR), 1.21; 95% confidence interval (CI), 1.07-1.36; P-trend = 0.02]. Among lean and normal weight women, statistically significant associations were observed for all tumors (RR, 1.27; 95% CI, 1.07-1.50) and for ER+ tumors (RR, 125; 95% CI, 1.03-1.52) and similar, but not statistically significant associations were found for ER- tumors (RR, 1.22; 95% CI, 0.76-1.93). The risk of breast cancer increased with increasing cadmium exposure similarly within each textile of whole grain/vegetable consumption and decreased with increasing consumption of whole grain/vegetables within each tertile of cadmium exposure (P-interaction = 0.73). Overall, these results suggest a role for dietary cadmium in postmenopausal breast cancer development. Cancer Res; 72(6); 1459-66. (C) 2012 AACR