p53 protein accumulation in colorectal cancer tissue has prognostic value only in left-sided colon tumours
p53 protein accumulation in colorectal cancer tissue has prognostic value only in left-sided colon tumours
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DOI：
10.1016/j.cdp.2004.05.001
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发表时间：
2004-01-01
影响因子：
--
通讯作者：
Paszkowska, A
中科院分区：
文献类型：
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作者：
Paluszkiewicz, P;Berbec, H;Paszkowska, A
本文的目的是描述一项前瞻性的10年随访研究，研究癌细胞中p53蛋白积累与结直肠肿瘤定位的预后价值。方法：采用免疫组织化学方法对80例散发性结直肠癌患者肿瘤组织样本中p53蛋白的积累进行了评估。结果：直肠肿瘤中p53蛋白的积累多于结肠肿瘤。在独立于原发肿瘤部位的癌细胞中p53蛋白积累的患者中观察到较低的生存率。左侧结肠癌患者组的累积生存率明显较低。p53蛋白积累是左侧结肠肿瘤的独立预后因素。结论：右侧结直肠肿瘤可能以p53不依赖的方式发展，p53蛋白在癌细胞中的积累仅在左侧结直肠肿瘤中具有预后价值。(C) 2004国际预防肿瘤学会。Elsevier Ltd.出版。版权所有。
The aim of this paper is to describe the prospective 10-year follow-up study of prognostic value of p53 protein accumulation in cancer cells in relation to the localisation of tumour in colorectum. Methods: The p53 protein accumulation has been assessed immunohistochemically in tumour tissue samples obtained from 80 selected sporadic colorectal cancer patients. Results: p53 protein accumulation was detected more often in rectum than in colon tumours. Lower survival rates were observed in patients with p53 protein accumulation in cancer cells independent of primary tumour site. Significantly lower cumulative survival rate was detected in the group of patients with left-sided colon cancer. The p53 protein accumulation was an independent prognostic factor in the left-sided colon tumours. Conclusions: The right-sided colon tumours may be developed in p53-independent manner and p53 protein accumulation in cancer cells has prognostic value only in the left-sided colorectal tumours. (C) 2004 International Society for Preventive Oncology. Published by Elsevier Ltd. All rights reserved.