Neural correlates of reexperiencing, avoidance, and dissociation in PTSD: Symptom dimensions and emotion Dysregulation in responses to script-driven trauma imagery
Neural correlates of reexperiencing, avoidance, and dissociation in PTSD: Symptom dimensions and emotion Dysregulation in responses to script-driven trauma imagery
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DOI：
10.1002/jts.20284
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发表时间：
2007-10-01
影响因子：
3.3
通讯作者：
Lanius, Ruth A.
中科院分区：
文献类型：
--
作者：
Hopper, James W.;Frewen, Paul A.;Lanius, Ruth A.
研究表明，创伤后应激障碍（PTSD）中对脚本驱动的创伤意象的反应包括重新体验和分离症状亚型。这项功能性磁共振成像 (fWRI) 研究采用了一种维度方法来表征脚本驱动的意象反应，使用对脚本驱动意象反应量表以及创伤后症状严重程度和神经激活之间关系的相关分析。正如预测的那样，重新体验的严重程度与右前岛叶活动呈正相关，与右喙前扣带皮层 (rACC) 呈负相关。回避与 rACC 和胼胝体下前扣带回活动呈负相关。此外，正如预测的那样，解离与左侧内侧前额叶和右侧颞上皮层的活动呈正相关，与左侧颞上皮层呈负相关。讨论了理论和临床意义，特别是关于 PTSD 的情绪失调解释。
Research suggests that responses to script-driven trauma imagery in posttraumatic stress disorder (PTSD) include reexperiencing and dissociative symptom subtypes. This functional magnetic resonance imaging (fWRI) study employed a dimensional approach to characterizing script-driven imagery responses, using the Responses to Script-Driven Imagery Scale and correlational analyses of relationships between severity of state posttraumatic symptoms and neural activation. As predicted state reexperiencing severity was associated positively with right anterior insula activity and negatively with right rostral anterior cingulate cortex (rACC). Avoidance correlated negatively with rACC and subcallosal anterior cingulate activity. In addition, as predicted, dissociation correlated positively with activity in the left medial prefrontal and right superior temporal cortices, and negatively with the left superior temporal cortex. Theoretical and clinical implications are discussed, particularly with respect to an emotion-dysregulation account of PTSD.