Phosphocitrate prevents disease progression in murine progressive ankylosis.
Phosphocitrate prevents disease progression in murine progressive ankylosis.
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DOI：
10.1002/art.1780361116
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发表时间：
1993-11
影响因子：
--
通讯作者：
H. Krug;M. Mahowald;P. Halverson;J. Sallis;H. Cheung
中科院分区：
文献类型：
--
作者：
H. Krug;M. Mahowald;P. Halverson;J. Sallis;H. Cheung
目的观察自发性关节病--进行性强直小鼠体内应用磷酸柠檬酸盐(PC)对疾病进展的影响。方法将年龄、体重、性别匹配的进展性强直小鼠分为两组，分别用PC或生理盐水治疗6周。结果在临床、组织学和显微放射学上，PC组和生理盐水组小鼠的疾病进展和严重程度有显著差异。结论PC可抑制小鼠进行性强直的病情进展。
OBJECTIVE Mice with progressive ankylosis, a spontaneous arthropathy, were treated with phosphocitrate (PC) in vivo to determine the effect of PC on disease progression. METHODS Two groups of mice with progressive ankylosis (matched for age, weight, and sex) were treated parenterally for 6 weeks with either PC or saline vehicle. RESULTS Clinically, histologically, and microradiographically, there were significant differences in disease progression and severity in the PC-treated and the saline-treated mice. CONCLUSION PC appears to inhibit disease progression in murine progressive ankylosis.