Peripheral metabolic actions of leptin
Peripheral metabolic actions of leptin
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DOI：
10.1079/pns19980064
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发表时间：
1998-08-01
影响因子：
7
通讯作者：
Emilsson, V
中科院分区：
文献类型：
--
作者：
Cawthorne, MA;Morton, NM;Emilsson, V
肥胖基因产物瘦素主要在脂肪组织中产生。在ob/ob小鼠中，ob基因的突变阻止了正常瘦素的产生，并导致了以肥胖和糖尿病为特征的表型(Zhang等人。(1994年)。向肥胖/肥胖小鼠每日注射重组瘦素可抑制食物摄入，减轻体重和脂肪量(Campfield等人。1995年；Halaas等人。1995年；Pelleymounter等人。这种治疗也使肥胖/肥胖小鼠的血糖浓度正常化，并降低了血浆胰岛素浓度(Pelleymounter等人。1995年)。给予瘦素的肥胖/肥胖小鼠的血糖和胰岛素敏感性的变化可能是减肥作用的简单结果。然而，在配对喂养研究中，注射瘦素不仅比配对喂养的小鼠体内脂肪减少得更多，而且血浆胰岛素浓度的减少也比同等减少食物摄入量所产生的减少要大得多(Levin等人)。1996年)。这些发现向我们表明，瘦素可能对一些与能量代谢相关的外周组织有直接影响，包括内分泌胰腺和骨骼肌。
The ob gene product, leptin, is produced predominantly in adipose tissue. In ob/ob mice, a mutation in the ob gene prevents normal leptin production and results in a phenotype characterized by obesity and diabetes (Zhang et al. 1994). Daily injections of recombinant leptin to ob/ob mice inhibit food intake and reduce body weight and fat mass (Campfield et al. 1995; Halaas et al. 1995; Pelleymounter et al. 1995).This treatment also normalizes the blood glucose concentration and reduces the plasma insulin concentration of ob/ob mice (Pelleymounter et al. 1995). It was possible that the changes in glycaemia and insulin sensitivity in ob/ob mice given leptin might be a simple consequence of the antiobesity action. However, in pair-feeding studies, infusion of leptin not only resulted in a greater reduction in body fat than in the pair-fed mice, but the reduction in the plasma insulin concentration was much greater than that produced by an equivalent reduction in food intake (Levin et al. 1996). These findings suggested to us that leptin might have direct effects on a number of peripheral tissues associated with energy metabolism, including the endocrine pancreas and skeletal muscle.