CIRCULARITY OF MITOCHONDRIAL DNA
CIRCULARITY OF MITOCHONDRIAL DNA
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DOI：
10.1073/pnas.56.4.1215
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发表时间：
1966-01-01
影响因子：
11.1
通讯作者：
NASS, MMK
中科院分区：
文献类型：
--
作者：
NASS, MMK
有证据表明，L细胞的线粒体DNA无论是从细胞器中挤压出来还是用苯酚提取出来，都是以环状形式存在的。核DNA是线性的。线粒体DNA似乎在一个或多个位点被膜结合。用电镜和化学方法测定线粒体DNA的分子量。单个线粒体中可能存在2至6个分子量为10 x 106的环分子。这些研究结果的一些影响进行了讨论。
Evidence has been presented that mitochondrial DNA of L cells exists in circular form either when extruded from osmotically lysed organelles or extracted by phenol. In contrast, nuclear DNA is linear. Mitochondrial DNA appears to be membrane-bound at one or more sites. The molecular weight of mitochondrial DNA was estimated by electron microscopic and by chemical methods. Two to 6 ring molecules of molecular weight 10 x 106 may be present in single mitochondrion. Some of the implications of these findings were discussed.