Is blue light a red herring in a rodent model of "computer vision syndrome"?
Is blue light a red herring in a rodent model of "computer vision syndrome"?
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在“计算机视觉综合症”啮齿动物模型中，蓝光是转移注意力的吗？
DOI：
10.1097/j.pain.0000000000002941
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发表时间：
2023
期刊：
影响因子：
7.4
通讯作者：
Jacobs,DeborahS
中科院分区：
文献类型：
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作者：
Moulton,EricA;Galor,Anat;Ciolino,JosephB;Jacobs,DeborahS
我们饶有兴趣地阅读了Gao等人最近发表的文章《C57BL/6J小鼠蓝光应激引起的眼痛觉和神经性疼痛》。作者提出了令人信服的发现，暴露于12小时环境蓝光/12小时黑暗周期的啮齿动物可以产生有害行为和与眼部不适和干眼症一致的临床症状。他们还观察到三叉神经节中角膜投射神经元中TRPV1和P物质的上调。这些发现代表了动物眼痛研究的重要进展。我们写这封信是为了挑战这种断言，即该模型代表了使用蓝光的“眼神经性疼痛/计算机视觉综合征的小鼠模型”。的确，这篇文章是在人们越来越意识到“屏幕时间”对健康和福祉有害的时候发表的，然而，作者的研究结果与计算机视觉综合征（CVS）的临床和科学相关性似乎存在缺陷，原因如下：
We read with great interest the recent article,“Ocular nociception and neuropathic pain initiated by blue light stress in C57BL/6J mice,” by Gao et al. 4 The authors present convincing findings that rodents exposed to 12-hour ambient blue light/12-hour dark cycles can produce nocifensive behaviors and clinical signs consistent with ocular discomfort and dry eye. They also observed an upregulation of TRPV1 and substance P in corneal-projecting neurons in the trigeminal ganglia. These findings represent an important advance for the study of ocular pain in animals. We are writing to challenge the assertion that this model represents “a mouse model of ocular neuropathic pain/computer vision syndrome” using blue light.It is true that this article comes at a time of increasing awareness of “screen time” as deleterious to health and well-being, yet the proposed clinical and scientific relevance of the authors' findings to computer vision syndrome (CVS) seems flawed for the following reasons:
了解和预防计算机视觉综合症。
DOI：
--
发表时间：
2008
期刊：
Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia
影响因子：
--
作者：
Ky Loh;Scott Redd
通讯作者：
Scott Redd