Reduced Alcohol Use Is Sustained in Patients Provided Alcohol-Related Counseling During Direct-Acting Antiviral Therapy for Hepatitis C.
Reduced Alcohol Use Is Sustained in Patients Provided Alcohol-Related Counseling During Direct-Acting Antiviral Therapy for Hepatitis C.
复制标题
在丙型肝炎直接抗病毒治疗期间提供酒精相关咨询的患者中持续减少酒精使用
DOI：
10.1007/s10620-020-06616-5
复制
发表时间：
2021-09
影响因子：
3.1
通讯作者：
Muir, Andrew J.
中科院分区：
文献类型：
--
作者：
Patel, Yuval A.;Yao, Jia;Proeschold-Bell, Rae Jean;Niedzwiecki, Donna;Goacher, Elizabeth;Muir, Andrew J.
关键词：
慢性丙型肝炎和危险/有害酒精使用患者的预后较差。评估丙型肝炎治疗期间酒精咨询是否影响纵向酒精消费的颗粒数据缺乏。评估在直接作用抗病毒丙型肝炎治疗的背景下，提供者提供的咨询是否与减少纵向酒精消耗有关。我们对丙型肝炎成人患者进行了辅助数据分析，这些患者在2014年10月至2017年9月期间接受了直接抗病毒治疗期间的咨询。总结了人口统计学和疾病特征。在直接作用抗病毒治疗之前、期间和之后，对饮酒、戒酒和大量饮酒进行评估。对所有患者和肝硬化亚样本进行多变量回归分析，以评估酒精摄入量与每12周时间段的关系。纳入123例患者；41人有肝硬化。以男性（74.0%）和黑人（58.5%）居多。在直接作用抗病毒治疗期间，酒精消耗量有所改善，并且显著持续（治疗前< 12周32.5 g/天；治疗期间20.0 g/天；治疗后12 - 24周23.7 g/天）。多变量分析显示，与治疗前< 12周相比，抗病毒治疗期间和治疗后的酒精消耗指标显著改善（治疗期间减少13.04 g/天，p = 0.0001；治疗后24周减少15.29 g/天，p = 0.0001）。肝硬化亚样本显示类似的结果（治疗期间减少13.21 g/天，p = 0.0001；治疗24周后减少7.69 g/天，p = 0.0001）。慢性丙型肝炎和高风险/有害酒精使用患者在丙型肝炎治疗期间接受提供者提供的酒精相关咨询后，在治疗期间和治疗后酒精消费模式持续减少。
Patients with chronic hepatitis C and risky/harmful alcohol use experience poor outcomes. Granular data evaluating whether alcohol counseling during hepatitis C treatment impacts longitudinal alcohol consumption are lacking. To evaluate whether provider-delivered counseling in the context of direct-acting antiviral hepatitis C treatment associates with decreased longitudinal alcohol consumption. We performed secondary data analysis from the Hep ART study including adults with hepatitis C who underwent provider-delivered counseling during direct-acting antiviral treatment between October 2014 and September 2017. Demographics and disease characteristics were summarized. Alcohol consumption, abstinence, and heavy drinking were evaluated in periods before, during, and after direct-acting antiviral treatment. Multivariate regression analyses were performed to evaluate the association of alcohol consumption with each 12-week time period for all patients and a subsample with cirrhosis. One hundred twenty-three patients were included; 41 had cirrhosis. Most patients were male (74.0%) and Black (58.5%). Alcohol consumption improved during direct-acting antiviral treatment and was notably sustained (< 12 weeks before treatment 32.5 g/day; during treatment 20.0 g/day; and 12–24 weeks after treatment 23.7 g/day). Multivariable analyses showed significantly improved alcohol consumption metrics during and after antiviral treatment compared to < 12 weeks before treatment (during treatment 13.04 g/day less, p = 0.0001; > 24 weeks after treatment 15.29 g/day less, p = 0.0001). The subsample with cirrhosis showed similar results (during treatment 13.21 g/day less, p = 0.0001; > 24 weeks after treatment 7.69 g/day less, p = 0.0001). Patients with chronic HCV and risky/harmful alcohol use given provider-delivered alcohol-related counseling during HCV treatment sustain decreased alcohol consumption patterns during and after treatment.
登录
查看更多内容
影响因子：
4.4
作者：
Bernstein, Edward;Topp, Deric;Bernstein, Judith
通讯作者：
Bernstein, Judith
DOI：
10.15288/jsa.2000.61.55
发表时间：
2000-01-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Babor, TF;Steinberg, K;Del Boca, F
通讯作者：
Del Boca, F
DOI：
10.1016/j.cgh.2016.11.034
发表时间：
2017-05
期刊：
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
影响因子：
--
作者：
Yang JD;Larson JJ;Watt KD;Allen AM;Wiesner RH;Gores GJ;Roberts LR;Heimbach JA;Leise MD
通讯作者：
Leise MD
影响因子：
25.7
作者：
通讯作者：
--
影响因子：
5.9
作者：
Burke, BL;Arkowitz, H;Menchola, M
通讯作者：
Menchola, M