Serologic markers of Epstein-Barr virus infection and nasopharyngeal carcinoma in Taiwanese men
Serologic markers of Epstein-Barr virus infection and nasopharyngeal carcinoma in Taiwanese men
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DOI：
10.1056/nejmoa011610
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发表时间：
2001-12-27
影响因子：
158.5
通讯作者：
Yang, CS
中科院分区：
文献类型：
--
作者：
Chien, YC;Chen, JY;Yang, CS
背景：EB病毒(EBV)可能在鼻咽癌发病中起一定作用，但尚未得到证实。我们确定鼻咽癌发生前是否存在抗EBV抗体。检测血液样本中抗EBV衣壳抗原的IgA抗体和抗EBV特异性DNA酶的中和抗体。在131,981人年的随访中，通过与台湾国家癌症登记中心的联系，确定了22例在招募后一年以上被诊断为鼻咽癌的病理确诊的新病例。结果两种血清标志物均未检测出阳性者，每10万人年患鼻咽癌的累积风险为11.2，有一种标志物的患者为45.0，同时有两种标志物的患者每10万人年的累积风险为371.0。在调整了年龄和有无鼻咽癌家族史后，这两个标记物的个体患鼻咽癌的相对风险为32.8%(95%可信区间，7.3%~147.2；P
Background It is probable but unproven that Epstein-Barr virus (EBV) has a role in nasopharyngeal carcinoma. We determined whether antibodies against EBV are present before the development of nasopharyngeal carcinoma.Methods A total of 9699 men were enrolled between 1984 and 1986. Blood samples were examined for IgA antibodies against EBV capsid antigen and neutralizing antibodies against EBV-specific DNase. During 131,981 person-years of follow-up, 22 pathologically confirmed new cases of nasopharyngeal carcinoma that were diagnosed more than one year after recruitment were ascertained through linkage with the National Cancer Registry of Taiwan.Results The cumulative risk of nasopharyngeal carcinoma per 100,000 person-years was 11.2 for subjects who tested positive for neither serologic marker, 45.0 for those who had one marker, and 371.0 for those who had both markers. After adjustment for age and the presence or absence of a family history of nasopharyngeal carcinoma, the relative risk of nasopharyngeal carcinoma was 32.8 for subjects with both markers (95 percent confidence interval, 7.3 to 147.2; P